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We at Crimson Publishing are a group of people with a combined passion for science and research, who wants...
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Crimson is an Open-access academic publisher has a vision to establish Open Science platform that seeks to provide equal opportunity for all, share and create knowledge, and enables the scholarly world to engage in a dialogue with the science in a more effective manner. Our efficient and transparent ways of peer-review procedures provide impact metrics for articles and researchers.
Our mission is to offer quality editorial services, significant resources into technology innovation, freely accessible, discoverable scientific information, and high-quality publications. Our impact metrics provide real time view on details such as views, downloads, and citations; demographies; aggregated author impacts; how author’s profile is perceived; social buzz; career visibility; integration across platform; and functionality.
Mini Review
Different Faces of Fas Signaling in Cancer Cells
Magdalena Szarynska* and Agata Olejniczak Kęder
Abstract
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Fas signaling pathway is known to be engaged in elimination of unwanted cells by apoptosis, however, new discoveries presented its alternate face, namely FasR and FasL play pro-cancerous functions facilitating cancer progression, invasion and metastasis. Here, we provide a brief summary of knowledge concerning Fas signaling pathway merits and disadvantages in cancer. Fas molecules were found to be engaged in many pathways induced by different therapeutic compounds, such as aspirin and antibiotics. This suggest that Fas signaling pathway may be employed as adjuvant factor for immunotherapy of variable design. Although, the literature presents some first optimistic results, we must intensify efforts to finally introduce Fas-associated procedures into standard therapeutic options......
Mini Review
Diabetes, Obesity and Atherosclerosis: Three Buds of One Stem MS-X
Metabolic Syndrome-X (MS-X) represents a medleybolome of several metabolic disorders from the angles of physiological, biochemical, clinical and metabolic anarchy. Diabetes, obesity and hypertension are the major medico-clinical concerns in 21st century both for developed and developing world. A great number of reports in last decades and recent past from various angles to control the pathology of MS-X have been published [1-9]. Exclusively, catching of diabetes in obese subjects is a unique feature in this disturbed metabolome. In human obesity the insulin resistance and type-2 diabetes are most often inter-linked. The feedback regulatory mechanism of hyper leptinemia is failed in human obesity [10,11]. On the other hand, hyperleptinemia develops insulin resistance. Th.....
Short Communication
Revisiting the Improvement of Respiratory System Protection of Mining Workers
The analysis of respiratory protective device use efficiency has shown the substantial limitations of qual-ity assessment for respirators. This results in potential hazard of excessive influence of harmful particu-late pollutants on employees. To prevent occupational diseases development, it is extremely important that employers are motivated to improve labour conditions. Not least important is development of re-quirements to the biomonitoring procedure and conditions, as well as selection, testing and users train-ing for individual respiratory protective devices use as based on the modern science development. The elimination of hazard class based only in providing the employees with individual respiratory protective devices is not scientifically substantiated and inadmissibl.....
Opinion
Thermal Comfort and Visual Comfort Inference for Residential Users
Christos Timplalexis*, Asimina Dimara, Stelios Krinidis and Dimitris Tzovaras
Indoor comfort can be described as a situation where building occupants are at a state of physical ease and well-being. Comfort is determined from the occupants’ perception of the environmental conditions according to their needs and objective senses. For indoor environments it is mainly defined by two factors, thermal and visual comfort. The proper regulation of thermal and visual conditions results in the elimination of any negative impact on the occupants’ execution of physical and cognitive activities .
Research Article
Evidences of Large-Scale Shearing from South-Eastern Extension of The Mahakoshal Belt, Covering Parts of Sidhi & Singrauli Districts of Madhya Pradesh and Sonbhadra District, Uttar Pradesh, India
The WNW-ESE trending arm of the Mahakoshal belt, extending towards south-east in the state of Jharkhand, through U.P, exposes variety of structural features those are uncommon in main Mahakoshals having ENE-WSW trend. The turbidites, said to be characteristic of the Parsoi Formation of the WNW trending arm, appear to be shear generated structures, having imprints across the length and width of the arm. Evidences of bulk flow along the pervasive foliation make it a mylonitic foliation, restricting possibility of survival of primary structures. Overwhelming presence of anticlockwise rotated fabric elements, producing S-C structure in phyllite/phyllonite and in meta-greywacke, along with frequent presence of ‘alpha’ and .....
Research Article
A Few Words about Food Science and Nutrition and its Impact on Aging and Age‐Associated Diseases
Food science and nutrition science are equally important and mutually dependent scientific disciplines. Due to demographic transition, older population has increased, and it has been observed that there has been a transition in terms of caregivers. Although there is uniformity in nature and habit, heterogeneity in terms of social, economic, physical and food frequency among the older is observed. Thus, it is necessary to study the food habit and nutritional status of the aged persons. Besides conceptual study, this paper highlights the impact of food science and nutrition on aging and age-associated diseases in general and in Old Aged Homes in Purulia, India.
Mini Review
Social Accounting vs Aging and Gerontology in Developing World
The article explores how healthy aging is derived from other factors such as suitable food, medications and environmental conditions. Such conditions could be provided through the practice of social accounting. The ever-changing conditions of the current times could be better fixed up, if the increasing aging people can remain in a healthy condition. Sociologically speaking, planners and policy makers must know that human behavior does not remain stable, instead, due to change in human wants and aspirations, social accounting must be applied from different angles. However, adopting healthy habits and behaviors, staying involved in one’s community, using preventive services, managing health conditions, and having access to all sources of medications can contribute to a produc.....
Opinion
Unknown Strong Earthquakes of The North-Western Caucasus in Holocene and Long-Term Seismic Regime
Studies and mapping on terrain seismogenic areas and determination of their modern seismic potential for the territory of the North-Western (Russian) Caucasus was fulfilled. With the especial detailed where explored areas of largest neotectonic faults in the region. On the south limb of the North-Western Caucasus near the important tectonic boundary between the Caucasus folded belt and the Transcaucasian microplate the primary and secondary seismic ruptures of unknown ancient and known historical strong earthquakes (seismic faults, landslides, fissures) were discovered. Using an informative method of trenching enable to estimate a recurrence interval of seismic shocks in a few seismic faults. This study in trenches to manage to define an absol.....
Opinion
Challenges of Mining in the Brazilian Amazon
The current environmental disasters caused by the mining sector in Brazil, Mariana and Brumadinho in Minas Gerais State, created a great concern on the practice of this activity in the Amazon. The Mining Industry in the Amazon is one of the most profitable industries in Brazil, e.g, for the Pará State the mining industry represented 4% of the GDP–Gross Domestic Product-and generated 180,000 direct jobs. Nowadays, in the Amazon, the mining industry challenges are the absence of technologies capable of increasing exploitation and reducing hazards associated to this activity. Stated as region of expansion for the Brazilian Mining Sector, the mining industry in the Amazon generates concerns due to its territorial expansion that represents 60% of Brazil.....
Research Article
Use of RPE for Monitoring Intensity Throughout Collegiate Basketball Drills
The ability to control and monitor the perception of training load is an important aspect of effective coaching.
Purpose: To examine the relation between OMNI ratings of perceived exertion and MET levels of intensity measures throughout a series of collegiate basketball drills.
Methods: 16 collegiate female basketball players (age 19.2±1.2 years) participated in this investigation. Participants engaged a 30-minute basketball skills session. The 30-minute basketball workout was created to simulate the high intensity environment of a Division I practice or game. Drills were selected to reflect the major skills needed to play the game of basketball. Each drill was also chosen because of its widespread use in the college basketball setting. The drills.....
Mini Review
Regenerative Medicine: A Multidisciplinary Approach to a Complex Problem
Carlotta Pucci1*, Chiara Martinelli and Gianni Ciofani
Despite the successful progresses in organ transplant, the organs shortage and the long waiting lists make it of the most challenging issues of our times. In fact, just a small percentage of patients receive transplants [1,2]. while every day around 18 people die waiting for them [3]. The possibility to create de novo tissues and organs and/or to promote their regeneration is of prominent interest in the research community. In the last years, many innovative approaches have been introduced and new technological advancements are undergoing. Currently, the most diffused methodologies rely on regenerative medicine, that combines the use of stem cells, stimulated with specific factors, and scaffolds, where cells can grow to substitute damaged tissues, inducin.....
Research Article
Comparative Bioavailability of a New Fixed Dose Combination Tablet Containing Lumacaftor/Ivacaftor in Healthy Subjects: A Randomized, Single-Dose, 2-Way Crossover Study
Lumacaftor and ivacaftor, a CFTR modulator that comprises both a CFTR corrector and potentiator, is indicated as a fixed dose combination tablet for the treatment of cystic fibrosis in patients ≥12 years old with homozygous F508del-CFTR. The CFTR is a protein chloride channel responsible for the regulation of salt and water absorption and secretion. The purpose of this study was to compare rate and extent of absorption and to evaluate the bioequivalence between a new pharmaceutical equivalent film-coated tablet formulation containing a fixed-dose combination of lumacaftor/ivacaftor 200/125mg and the innovator product.
Research Article
Quantitative Analysis of Electroencephalographic Background Activity in NREM Sleep in Childhood Epilepsy with Centrotemporal Spikes
Childhood epilepsy with centrotemporal spikes (also known as Rolandic epilepsy) is one of the most frequent epileptic syndromes in childhood. Diagnosis is based on typical seizures and electroencephalographic features: symmetric background EEG activity, well organized, with normal reactivity in wakefulness and normal sleep patterns; interictal rolandic epileptiform discharges. Quantitative analysis of the EEG recording (QEEG) is a way of assessing the brain’s electrical activity. Compared with analog EEG, it provides additional data in neurological disorders where no structural brain damage is present, but rather an alteration of how the brain evaluates information. In epilepsy, QEEG studies are limited.
Opinion
Introducing SAMS
Conventional medicine is based on the Germ Theory. Alternative/complementary forms of therapy include acupuncture, aromatherapy, chiropractic, homeopathy, naturopathy, oste-opathy, reflexology, ayurvedic and reiki [1]. The Germ-Terrain duality theory of disease states that the etiology of certain diseases/diseased states is better explained as a complex inter-play between germs and the inherent anatomical/physiological integrity of the body cells. It argues that the etiology of certain diseases is not fully explained merely by the presence of germs (Germ Theory) or by a mere loss of cellular integrity (Terrain Theory). As a result, the prevention and treatment of such diseases should focus not just on fighting germs but on maintaining/restoring the anatomical/physiological .....
Opinion
Introducing SASS
“Any sufficiently advanced technology is indistinguishable from magic” Arthur C Clarke. “Mop up operations are what engage most scientists throughout their careers. This paradigm-based research is an attempt to force nature into the pre-formed and relatively inflexible box that the paradigm supplies. No effort is made to call forth new sorts of phenomena, no effort to discover anomalies. When anomalies pop up, they are usually discarded or ignored. Anomalies are usually not even noticed, and no effort is made to invent a new theory-and there is no tolerance for those who try” Thomas Kuhn [1]. SASS is an acronym for Seun Ayoade’s Surgical System. It is surgery involving the microzymas [cellular dust] and the Primo Vascular System, that is to say surgery based on the Germ Terrain D.....
Mini Review
Forensic Application of DNA Methylation in Age-Prediction
Advances in Epigenetics suggested that DNA methylation profiling, plays an important role in various
biological process such as silencing, maintaining or expression of genomic stability. DNA methylation is
the most comprehensively studied epigenetic mark, and it involves the addition of a methyl group to the 5′ cytosine of CG dinucleotide, referred to as CpGs. DNA methylation is related to gene regulation and cell differentiation by affecting transcription factor binding sites, insulator components, and chromosome morphology. Recent advances suggested that DNA methylation markers not only can provide information about tissue of origin of evidence sample, but also can rely information about the age and lifestyle or environmental exposure of an individual, for an unknown suspect. In this.....
Research Article
Design, Realization and Characterization of a Wide-Angle Microwave Metasurface Absorber
In this article, we present a metasurface absorber (MMA) based on a periodic structure consisting of double split-ring resonators (dSRR) which efficiently absorbs electromagnetic radiation for a wide range of incidence angles for both the transverse electric (TE) and the transverse magnetic (TM) polarizations. The proposed unit cell was designed employing a full 3-D electromagnetic solver based on the Finite Element Method (FEM). The unit cell consists of a square split-ring resonator and a thin metallic plate separated by a dielectric layer. Investigations of parameterization and optimization have shown that small modifications in the geometry of the resonator led to enhanced angular absorption. The numerical simulation stage was followed by design and fabrication of a prototype containi.....
Mini Review
Review of Noncontact Ultrasonic Measurement System for Structural Health Monitoring
Makiko Kobayashi*, Wu KT and Riichi Murayama
Non-destructive testing (NDT) of infrastructure such as bridges and tunnels has become more important since it has aging problem and traffic was heavier than expected. Thin film ultrasonic sensors would be attractive because it is easy to integrate on huge structure. However, NDT of huge structure is still challenging because of sensor accessibility. Semi-noncontact ultrasonic sensors were proposed in this manuscript. 20cm diameter copper coil transmit/receive electrical signal from a pulser/receiver instrument and a thin film ultrasonic sensor and reflected echo from 12.7mm thick steel plate successfully. By this method, measurement using drone could be possible and it increases application possibility for huge infrastructure monitoring.
Case Report
The Great Masquerader: Pulmonary Embolism
Syed T Alam* and Syed Tabish Ahsan
We present the case of a 49-year-old male who was referred from Emergency department with worsening breathlessness, chest tightness for last 24 hours. He had a background history of Asthma and Hyper-tension. Initial ECG revealed symmetric T wave inversions in anterior leads and found to have raised troponin levels. Patient was diagnosed and treated as NSTEMI. While waiting for his coronary angiogram he underwent echocardiogram whose findings were consistent with right sided impairment. Differential diagnosis of Pulmonary Embolism has been made and CT Pulmonary Angiogram done that confirmed diagnosis of Pulmonary Embolism. Early advice from the Respiratory team was sought and patient was treated with rivaroxaban. After a hospital stay, he made a remarkable rec.....
Research Article
FRS105
In 2015 The standard FRS 105 was introduced for micro entities eligible under company law in the UK.
FRS 105 generally follows the principles applied to the main accounting standard in the UK and Republic of Ireland (FRS 102). It is further simplified in terms of recognition, measurement and disclosure. By asking four relevant questions we will empirically assess the extent that the new micro company regime has been taken up in the UK. In this report we used FAME database to empirically test the questions.
Mini Review
Bioengineered Tooth-A New Horizon
Dental mesenchymal stem cells are an attractive source of autologous stem cells. They offer a biological solution for restoring damaged dental tissues such as vital pulp and periodontal ligament and even, generation of complete or partial tooth structures to form biological implants through tissue engineering. Thus, dental tissue engineering is a new promising therapeutic approach to replace a missing tooth or to restore the damaged dental tissues. The objective of this review article is to highlight the history of the isolation of dental-related stem cells and their various types along with their potentiality and current status of applications in the field of dentistry.
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