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Crimson is an Open-access academic publisher has a vision to establish Open Science platform that seeks to provide equal opportunity for all, share and create knowledge, and enables the scholarly world to engage in a dialogue with the science in a more effective manner. Our efficient and transparent ways of peer-review procedures provide impact metrics for articles and researchers.
Our mission is to offer quality editorial services, significant resources into technology innovation, freely accessible, discoverable scientific information, and high-quality publications. Our impact metrics provide real time view on details such as views, downloads, and citations; demographies; aggregated author impacts; how author’s profile is perceived; social buzz; career visibility; integration across platform; and functionality.
Mini Review
Regenerative Medicine: A Multidisciplinary Approach to a Complex Problem
Carlotta Pucci1*, Chiara Martinelli and Gianni Ciofani
Abstract
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Despite the successful progresses in organ transplant, the organs shortage and the long waiting lists make it of the most challenging issues of our times. In fact, just a small percentage of patients receive transplants [1,2]. while every day around 18 people die waiting for them [3]. The possibility to create de novo tissues and organs and/or to promote their regeneration is of prominent interest in the research community. In the last years, many innovative approaches have been introduced and new technological advancements are undergoing. Currently, the most diffused methodologies rely on regenerative medicine, that combines the use of stem cells, stimulated with specific factors, and scaffolds, where cells can grow to substitute damaged tissues, inducin.....
Research Article
Comparative Bioavailability of a New Fixed Dose Combination Tablet Containing Lumacaftor/Ivacaftor in Healthy Subjects: A Randomized, Single-Dose, 2-Way Crossover Study
Lumacaftor and ivacaftor, a CFTR modulator that comprises both a CFTR corrector and potentiator, is indicated as a fixed dose combination tablet for the treatment of cystic fibrosis in patients ≥12 years old with homozygous F508del-CFTR. The CFTR is a protein chloride channel responsible for the regulation of salt and water absorption and secretion. The purpose of this study was to compare rate and extent of absorption and to evaluate the bioequivalence between a new pharmaceutical equivalent film-coated tablet formulation containing a fixed-dose combination of lumacaftor/ivacaftor 200/125mg and the innovator product.
Research Article
Quantitative Analysis of Electroencephalographic Background Activity in NREM Sleep in Childhood Epilepsy with Centrotemporal Spikes
Childhood epilepsy with centrotemporal spikes (also known as Rolandic epilepsy) is one of the most frequent epileptic syndromes in childhood. Diagnosis is based on typical seizures and electroencephalographic features: symmetric background EEG activity, well organized, with normal reactivity in wakefulness and normal sleep patterns; interictal rolandic epileptiform discharges. Quantitative analysis of the EEG recording (QEEG) is a way of assessing the brain’s electrical activity. Compared with analog EEG, it provides additional data in neurological disorders where no structural brain damage is present, but rather an alteration of how the brain evaluates information. In epilepsy, QEEG studies are limited.
Mini Review
Forensic Application of DNA Methylation in Age-Prediction
Advances in Epigenetics suggested that DNA methylation profiling, plays an important role in various
biological process such as silencing, maintaining or expression of genomic stability. DNA methylation is
the most comprehensively studied epigenetic mark, and it involves the addition of a methyl group to the 5′ cytosine of CG dinucleotide, referred to as CpGs. DNA methylation is related to gene regulation and cell differentiation by affecting transcription factor binding sites, insulator components, and chromosome morphology. Recent advances suggested that DNA methylation markers not only can provide information about tissue of origin of evidence sample, but also can rely information about the age and lifestyle or environmental exposure of an individual, for an unknown suspect. In this.....
Research Article
Design, Realization and Characterization of a Wide-Angle Microwave Metasurface Absorber
In this article, we present a metasurface absorber (MMA) based on a periodic structure consisting of double split-ring resonators (dSRR) which efficiently absorbs electromagnetic radiation for a wide range of incidence angles for both the transverse electric (TE) and the transverse magnetic (TM) polarizations. The proposed unit cell was designed employing a full 3-D electromagnetic solver based on the Finite Element Method (FEM). The unit cell consists of a square split-ring resonator and a thin metallic plate separated by a dielectric layer. Investigations of parameterization and optimization have shown that small modifications in the geometry of the resonator led to enhanced angular absorption. The numerical simulation stage was followed by design and fabrication of a prototype containi.....
Mini Review
Review of Noncontact Ultrasonic Measurement System for Structural Health Monitoring
Makiko Kobayashi*, Wu KT and Riichi Murayama
Non-destructive testing (NDT) of infrastructure such as bridges and tunnels has become more important since it has aging problem and traffic was heavier than expected. Thin film ultrasonic sensors would be attractive because it is easy to integrate on huge structure. However, NDT of huge structure is still challenging because of sensor accessibility. Semi-noncontact ultrasonic sensors were proposed in this manuscript. 20cm diameter copper coil transmit/receive electrical signal from a pulser/receiver instrument and a thin film ultrasonic sensor and reflected echo from 12.7mm thick steel plate successfully. By this method, measurement using drone could be possible and it increases application possibility for huge infrastructure monitoring.
Case Report
The Great Masquerader: Pulmonary Embolism
Syed T Alam* and Syed Tabish Ahsan
We present the case of a 49-year-old male who was referred from Emergency department with worsening breathlessness, chest tightness for last 24 hours. He had a background history of Asthma and Hyper-tension. Initial ECG revealed symmetric T wave inversions in anterior leads and found to have raised troponin levels. Patient was diagnosed and treated as NSTEMI. While waiting for his coronary angiogram he underwent echocardiogram whose findings were consistent with right sided impairment. Differential diagnosis of Pulmonary Embolism has been made and CT Pulmonary Angiogram done that confirmed diagnosis of Pulmonary Embolism. Early advice from the Respiratory team was sought and patient was treated with rivaroxaban. After a hospital stay, he made a remarkable rec.....
Research Article
FRS105
In 2015 The standard FRS 105 was introduced for micro entities eligible under company law in the UK.
FRS 105 generally follows the principles applied to the main accounting standard in the UK and Republic of Ireland (FRS 102). It is further simplified in terms of recognition, measurement and disclosure. By asking four relevant questions we will empirically assess the extent that the new micro company regime has been taken up in the UK. In this report we used FAME database to empirically test the questions.
Mini Review
Bioengineered Tooth-A New Horizon
Dental mesenchymal stem cells are an attractive source of autologous stem cells. They offer a biological solution for restoring damaged dental tissues such as vital pulp and periodontal ligament and even, generation of complete or partial tooth structures to form biological implants through tissue engineering. Thus, dental tissue engineering is a new promising therapeutic approach to replace a missing tooth or to restore the damaged dental tissues. The objective of this review article is to highlight the history of the isolation of dental-related stem cells and their various types along with their potentiality and current status of applications in the field of dentistry.
Mini Review
Identifying Biomarkers for Diffuse Large B-Cell Lymphoma Subtypes
Diffuse Large B-cell Lymphoma (DLBCL) is a highly heterogeneous cancer of B cells. Apart from cell-of-or-igin, genetic variations have been observed to contribute towards heterogeneity leading to different path-ogenic mechanisms and overall survival outcomes. Various classification schemes have been proposed that may aid in risk stratification and developing new therapeutics for those who fail frontline therapy. This mini review highlights the significance of genetic variations as biomarkers for DLBCL and ease in extending it to clinical setting.
Short Communication
Octopus Clubfoot Rediscovered - World’s First Exotic Case - A Neglected, Triple Axes Rotational, Grade 3 Extreme Deformity: Corrected by, Unparalleled, 4-In-1 Mega Surgical Skin Expansion from Crooked to ROZY Foot
Octopus clubfoot is the world’s first, the most spectacular severe/ rigid BIZARRE deformity with this new catchy name given by the author. This 18-year-old girl was operated by 4-in-1 unifying incision (first ever four well known plastic surgery procedures in one incision) with excellent, extremely gratifying, normal looking foot, without any arthrodesis. During The Intervening Period, Numerous, Highly Signifi-cant, Firsts Were Discovered relating to this case, having potential for changing global thinking of treating highly prevalent varied neglected deformities, prevalent globally, more in LMICs (as reported in author’s SICOT article at (Table 1) and Clubfoot Book by Taylor & Francis 2018, available, the world over, on Google search). It displayed an awesome show in print media and G.....
Mini Review
Performance Emulsifiable Vegetable Cutting Fluid Lubricant Vermicular Cast Iron Milling Process
Sartori Moreno JR* and Lopes da Silva G
The vegetable-based fluids have been increasingly used in industry because, in addition to pollute less cause less harm to the operator and provide a significant improvement in tool life. To perform this job temperature sensor adjustments were made on a simulation machine Reichert Wear Test type which has the function of providing simulations of friction and wear under controlled conditions, tests which were performed with vegetable oils lubrificants.
Research Article
Antipsychotic Induced Malignant Syndrome: A Native Inpatient Evaluation
Shafti SS*, Memarie A, Rezaie M and Hamidi M
Introduction: Neuroleptic malignant syndrome (NMS) is a life-threatening complication that can occur anytime during antipsychotic treatment. In the present assessment the incidence and clinical profile of NMS have been probed among a sample of non-western psychiatric inpatients and compared with the available data in literature regarding prevalence and other associated clinical physiognomies.Methods: As a retrospective, record based evaluation, all cases that had been diagnosed absolutely as NMS during the last sixty-two months, after ruling out other imaginable differential diagnosis, like encephalitis, meningitis and serotonin syndrome, had been included in the present investigation. Clinical diagnosis, as well, was based on Diagnostic and Statistical Manual of Mental Disorders, 5th edit.....
Research Article
Electronic Health Records and Teaching Status Effects on Mortality in New York State Hospitals
Daniel O’Malley and Eduard Babulak*
Becoming more efficient and increasing the quality of healthcare delivery has been a recurring theme in the U.S. for decades. Recently, electronic health records have been touted as a technology-centric path toward healthcare efficiency and quality, with the Federal government incentivizing large-scale adoption of these systems. The purpose of this quantitative correlational study was to examine the quality differences between teaching and non-teaching hospitals in the post-electronic health record implementation landscape, specifically looking at a possible interaction effect between electronic health records and hospital teaching status. The results of this study showed pneumonia mortality was slightly higher at teaching hospitals, despite the ra.....
Case Report
Abdominal Compartment Syndrome in Child with Acute Viral Hepatitis B: Case Report
Yevtushenko V*, Kramarov S and Markov A
Background: Renal involvement in idiopathic hyper-eosinophilic syndrome is uncommon. The mecha-nism of kidney damage can be explained as occurring via two distinct pathways: thromboembolic isch-emic changes secondary to endocardial disruption mediated by eosinophilic cytotoxicity to the myocar-dium and direct eosinophilic cytotoxic effect to the kidney.Case presentation: We present a case of a neonate who admitted to our hospital with severe form of acute hepatitis B. During acute period of illness, he was diagnosed with abdominal hypertension and abdominal compartment syndrome. This complication associated with progression of multiorgan failure. Conservative treatment was effective to achieve full recovery.Conclusion: Course of acute viral hepatitis B in c.....
Opinion
Effective and Ideal Separation Factors at Sublimation Refining of Sm, Eu, Tm, Yb
It is shown that the application of ideal separation factor in calculations of high-temperature sublimation refining of Sm, Eu, Tm and Yb has confined character: in considered base-impurity systems a difference between effective (β) and ideal (βi) separation factors increases with deviation of βi from unity and can be very significant; the measurable difference (in limited of a one order) between β and ideal βi is observed at deviation of βi from unity not more than 2 orders. The discrepancies between the effective and ideal separation factors in evaporative refining processes (distillation and sublimation at low impurity content) are not associated with the chemical interaction of the components.
Review Article
Computer-Aided Porous Materials Description Based on Morphological Spectra
A new approach to porous materials features evaluation is proposed in the paper. The method consists in computer analysis of microscope images of porous material sections. Instead of individual pores analysis, in this approach global morphological spectra (MS) of the images are examined. It is shown that MS contain full information about the morphological structure of the porous material section. Porosity evaluation is then formulated as a statistical MS classification task and a method of its solution is proposed.
Mini Review
Improved Structural and Optical Properties Of C(Carbon)-Supported Zno Nanorod Arrays
We have fabricated as-grown ZnO nanorods (NRs) and C(carbon)-supported NRs arrays on semi-insulat-ing (100)-oriented Si substrates. Field emission scanning electron microscopy, X-ray diffraction, revealed that the as-grown ZnO NRs and carbon-assisted ZnO NRs were single crystals with a hexagonal wurtzite structure, and grew with a c-axis orientation perpendicular to the Si substrate. These measurements show that the carbon-supported ZnO NRs were better synthesized vertically on a Si substrate compared to the as-grown ZnO NRs. Superconducting Quantum Interference Device showed that defect concentra-tion of the carbon-assisted ZnO NRs was remarkably reduced compared to the as-grown ZnO NRs. The reduced defect concentration of the carbon-supported ZnO demonstrates the p.....
Mini Review
Phytopathogenic Fungi: Useful Tools to Degrade Plant Biomass for Bioethanol Production
Gabriela Piccolo Maitan Alfenas*, Rafael Ferreira Alfenas and Valéria Monteze Guimarães
Phytopathogenic fungi are able to produce enzymes for cell wall degradation when they attack the hosts and there is a close relationship between the capacity of enzymatic secretion and the virulence of these microorganisms. These enzymes are promising for biotechnological purposes and plant biomasses play an important role for induction of their production by fungal species. Biomass is an economic alternative to reduce pollution and to produce renewable fuels. The fungal enzymes are mainly applied for the hydrolysis step of bioethanol production process, which is environmentally friend. Many phytopathogen fungi are considered promising for enzymes production such as Chrysoporthe cubensis, Ceratocystis fimbriata and Fusarium verticillioides.
Research Article
Empowering Living Matter and the Fever Effect of Global Warming
The amount of mechanical energy being produced by the muscles of all animals is so far several times more than the energy from all thermal engines created by human. But what is most wonderful, and we have to confess up to nowadays scientists do not understand the essence of the muscle process P. L. Kapitsa. This work explicates the physical basis of the material motions in living systems. Simplistic thinking sticks to an obvious seemingly unyielding scheme: nervous system sends control signals while the energy comes from the food. Such a trivial scheme is on par with robotics systems design supplementing artificial muscles with an extraneous supply of electrical energy. But how in living systems can energy appear immediately.....
Research Article
The Silent Voice of Those Who are no Longer: Transgenerational Transmission of Information from the Perspective of the Informational Model of Consciousness
The “nature or nurture” problem concerning the debate on the innate features with respect to the acquired ones is approached in terms of information, from the perspective of the Informational Model of Consciousness. This model reveals seven distinct informational systems reflected in consciousness as informational centers, i.e. memory (Iknow-Ik), decisional info-operational center (Iwant-Iw), emotions (Ilove-Il), metabolic operations (Iam-Ia), genetic transmission (Icreate-Ic), genetic info-generation (Icreated-Icd) and the anti-entropic center (Ibelieve-Ib). Ib is a life-assisting beneficial center, because it is opposed to the entropic action of matter, eliminating or reducing the uncertainty characteristic to .....
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