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Case Report
A Note on Disruptive Innovation Model of PDD Case
Abstract
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Full-Text
e-Pub
Pinduoduo e-commerce platform (NASDAQ: PDD) is a typical latecomer related with
disruptive innovation. When Pinduoduo entered China’s e-commerce field in 2015, it
already had various e-commerce platforms such as Taobao and others, among which Taobao
and Jingdong had a market share of more than 90%. Pinduoduo was facing the market
competition situation of oligopoly. Second, Pinduoduo is an undisputed disruptor of the
market. Pinduoduo adopts distributed AI technology that is different from other e-commerce
companies. It starts from the low-end market with the Pinduoduo mode and develops a lowend market of e-commerce with more than 300 million users in just three years by relying
on low-cost commodities [1-3]. At present, the market coverage of Pinduoduo has gradually
expanded from.....
Case Report
Protein S Deficiency and Pulmonary Embolism in Children: A Case Report and Review of Literature
Othman Rizk A Mishref*, Abdelrahman A Beridan and Amr Abdelmordy E Samaka
DOI: 10.31031/RPN.2021.05.000614
Protein S deficiency is a major risk factor for venous thromboembolism. Unprovoked life-threatening
pulmonary embolism is uncommon in children; however, it can pose a diagnostic challenge, presenting
in a non-specific and subtle way, masked by lack of typical presentation. Therefore, it is important for
pediatrician to consider pulmonary embolism as a differential diagnosis for young patients presenting
with severe unexplained parasternal chest pain with strong family history of thrombophilia and to have
a low threshold for requesting appropriate investigations. Here we present a young patient with acute
pulmonary embolism who was finally diagnosed as Type III Protein S deficiency
Research Article
Characterization of Coir Pith Ash Blended Cement Pastes
DOI: 10.31031/RDMS.2021.15.000851
More undesirable wastes or by-products are generated from the coconut and coir industry as coir pith.
The raw coir pith was fired up to 500 ºC inside a suitable oven to obtain Coir Pith Ash (CPA). The effect
of CPA as a supplementary cementitious material on the various specific characteristics of Portland
cement pastes was investigated. Results illustrated that the blaine fineness of the whole cement blend,
water of consistency and setting times increased with the increase of CPA addition. The bound water
content and bulk density as well as flexural and compressive strengths improved and enhanced with the
addition of CPA only up to 12wt % CPA (CP4), and then sharply decreased suddenly with further increase
of CPA content (CP5). The free lime content of the blended cement pastes co.....
Research Article
Synthesis and Anti-inflammatory Activity of Newly Synthesized 1,7-Dimethyl-4H-Benzo [D] [1,3]-Oxazin-4-One and 3-Amino-1,7- Dimethyl-Quinazolin-4(3H)-One
DOI: 10.31031/NRS.2021.06.000631
Background/Introduction: The synthetic studies of 4-quinazolinone derivatives have been
presented due to the chemical and biological interest. 4-Quinazolinone derivatives possesses antibacterial,
antifungal, amti-inflammatory, analgesic activities.
Aims and objectives: The objective of the present study was to synthesize these quinazolinone
derivatives 3-Amino 7-methyl-1-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-Amino-7-methyl-2-
methyl-3H-quinazolin-4-one and screened them for their anti-inflammatory activity.
Materials and methods: The condensation of 2-amino-methyl-5-methylbenzoate with acetic
anhydride yielded the cyclic compound 1, 1,7-dimethyl-4H-benzo[d]-[1,3]-oxazin-4-one which further
produce a novel 2,3-disubstituted-quinazolin-4 ones via the reaction with hydrazine hyd.....
Mini Review
Novel COVID-19 Treatment with Novel Therapy
DOI: 10.31031/NRS.2021.06.000632
The main purpose of this research is to laid down a new concept leading to increase the
survival rate of corona infected patients. As coronavirus is spreading widely in all over the
world and many deaths have been reported due to this life threatening disease. So in this
study, a new strategy has been introduced for the very old vitamin-D in order to put forward
that how vitamin-D can be used as a primary precursor for the treatment of novel coronavirus
and its relationship with Covid-19 effected individuals
Mini Review
Traditional Foods in Europe: Perceptions & Prospects in the New Business Era
DOI: 10.31031/MCDA.2021.08.000681
Traditional Foods (T.F.) in Europe constitute a minor part of the food chain, with the production and
consumption remaining within certain territories. They are healthy, unique innovative products, attractive
to the end consumer. COVID-19 will have an impact on the whole process from the field to the consumer
concerning issues such as food safety, food security bioactive ingredients, production, processing,
distribution. The current article explores the potentials of T.F. in the economic era after the pandemic
crisis. T.F. have the opportunity to grow and expand beyond their local areas in Europe, becoming major part of the food chain for the benefit of regional producers and communities
Mini Review
Pyruvate May be a Novel Intervention of Diabetes
DOI: 10.31031/IOD.2021.05.000602
Recent advances in pyruvate studies indicate that pyruvate may be a novel therapy in care of
diabetes and its organ complications. The major action of pyruvate protection against diabetes may be
in rejuvenation of glucose oxidation by preserving glycolysis and reactivating pyruvate dehydrogenase
activity in the tricarboxylic acid cycle, reversing the Warburg effect in diabetic glucometabolic disorders.
Pyruvate preservation of glucose metabolism plus its beneficial effects, such as anti-hypoxia, -oxidative
stress, -acidosis, -apoptosis and -advanced glycation end products and stimulation of insulin secretion,
may turn diabetic vicious circle virtuous in initiation and development of diabetic process. This review
proposed a novel opinion focused on pyruvate superior biomedical and ph.....
Opinion
Toolbox Application to Support and Enhance the Mobile Device Forensics Investigation Process
Bruno Bernardo* and Vitor Santos
DOI: 10.31031/FSAR.2021.05.000619
Throughout the study on the topic regarding Mobile Device Forensics, the authors
noticed the different challenges that arise from the digital investigation associated with
this science. Moreover, to address these different challenges, namely, the ones regarding the
lack of documentation, standardization and research on this science Chernyshev et al. [1];
Barmpatsalou et al. [2]; Omeleze and Venter [3], the authors studied not only the Forensics
field but also the Digital and Mobile Forensics ones, in other to understand the different and
critical challenges that are jeopardizing and affecting the accuracy and integrity of these
types of sciences and its investigations. As such, the authors proposed to study this field by
firstly performing a systematic literature review using the P.....
Case Report
Bacteremia due to Opportunistic Infection in Times of Pandemic
Alan Wiener, Jorge Dreyse* and Reinaldo Rosas
DOI: 10.31031/CJMI.2021.04.000600
Nosocomial infections are considered a public health issue. They display higher rates of drug –
resistant organisms. Immunosuppression is a risk factor to acquire a nosocomial infection. Various
publications have tried to demonstrate that COVID-19 disease induces a profound state of suppression in
patients, exposing them to nosocomial and opportunistic infections. We present a case of a 57-year-old
male patient with a severe case of COVID-19 pneumonia and Elizabethkingia miricola bacteremia
Mini Review
Herbal Expectorants for the Pandemic Period: A Review
Justin R Nayagam Saira George* and Sagna A
DOI: 10.31031/EAES.2021.08.000677
As the ongoing COVID 19 pandemics has become a global health crisis and it mainly affects
respiratory tract. An effort for presenting the traditional expectorents of the herbal medicine gains its
attention, which is promising for the world population from the plant genetic resources to reduce the
pressure on pharmacy for medicine. Herbal expectorants are proved to be environmentally safe and are
available in around any habitats. Forty-eight species of plants used traditionally as expectorants from six
continents are included in the present study. Plant parts used, its dosage forms, bioactive compounds
having expectorant activities are evaluated in the study. Abies webbiana Lindl. belongs to gymnosperm,
Adiantum capillus-veneries L. is a pteridophyte and 42 others are flowering plant.....
Research Article
Replacement of Sunflower Meal with Moringa Oleifera Leaves on Growth Performance of Broiler
Fida Noor Baloch*, Hafeez Noor Baloch and Gulfam Ali Mughal
DOI: 10.31031/APDV.2021.08.000682
Moringa oleifera leave are the protein source with an adequate profile of amino acids. The present
study was undertaken in order to determine the replacement of sunflower meal with moringa oleifera
leaves on growth performance of broiler. Birds were arbitrarily separated in four groups, i.e. A (control)
was offered 0% Moringa oleifer meal whereas; 1.25% (group B), 2.5% (group C) and 3.75% (group D)
Moringa oleifera leaves meal. Parameters measured were weight gains, feed intake, dressing percentage
and Feed conversion ratio calculated. Results showed that the maximum chicken body weight and feed
intake was noted in group C, as compared to other groups. Feed intake was minimum in group A (control).
The higher water intake was recorded in group C, followed by other groups. There was s.....
Research Article
Case Report: Abdominal Aortic Aneurysms
DOI: 10.31031/NRS.2021.06.000629
Abdominal Aortic Aneurysms (AAA) more commonly affect men and are estimated to affect 4%
to 8% of men older that age 60 years. There are two methods of repairing AAA, Open surgical repair
and Endovascular repair. While surgical treatment for Abdominal Aortic Aneurysm (AAA) is a standard
operation, prevention of complication is important. One of these complication is Aneurysmal dilatation at the anastomotic site or recurrent AAA
Research Article
Relativistic Equation of Motion in the Presence of a Moving Force Field
DOI: 10.31031/NRS.2021.06.000630
The paper presents a way to generalize a relativistic equation of dynamics to describe the movement
of a material particle in a force field with moving sources. In the static force field version, the equation
is identical to the standard equation of dynamics in special relativity. The same formula can also be
derived from the equation of motion for variable-mass systems with the additional assumption of the
energy-mass equivalence, instead of assuming the constancy of the speed of light. A new approach to the
dynamics of relativistic objects makes it possible to describe the magnetic interaction associated with the electric current of moving charges
Short Communication
Missing Black Holes
DOI: 10.31031/NRS.2021.06.000626
There is an answer to a missing black hole in certain galaxies and it includes an explanation
of the nature of black holes. There is a geometric component which affects our perspective of
the nature of space including for black holes. A few simple concepts at conflict with everyday
physics are useful here. Realize that everything that moves causes pressure or a push.
Anything thought of a pull or an attraction is caused by a push. So, gravity is some kind of push
and it functions across space. We also know that light and all other EM radiation forms move
across all of space and do so at speed c. In doing so the radiation pushes down upon us and
provides the effect of our gravity ‘attraction’. As there is nothing more throughout space then
the radiations make up the nature of sp.....
Mini Review
Protocol of Pain
DOI: 10.31031/NRS.2021.06.000627
When acute pain progresses to chronic, then it is not a symptom of a condition, but is in
itself a condition. It lasts longer than the expected course of the disease or injury. Usual period
of 3-6 months. In the past the answer to chronic pain was: “everything is in your mind”. A
useful definition by Margo McCaffrey is: “pain is what describes the person who experiences
it and exists when he says he exists [1].” The International Union for the Study of Pain says
it is “an unpleasant aesthetic and emotional experience, combined with actual or potential
tissue damage, or described in terms of such damage”. Pain is transmitted through the body
through the nervous system when nerve endings detect damage to a part of the body. Today,
pain specialists can understand how pain .....
Mini Review
Saccharomyces cerevisiae as A Fusion Inhibitor of Sars-Cov-2
DOI: 10.31031/NRS.2021.06.000628
SARS-CoV-2 interacts with prokaryotic translation elongation factors (eEFs), predominantly eEF1A.
This connection occurs at the intracellular level, when the virus is linked to ribosomes, necessary for
viral replication. The fungus Saccharomyces cerevisiae has an abundance of eEF1A protein, and its dietary
supplementation can increase serum protein levels, which, by binding to viruses circulating in the
blood, prevent the entry of these cells, thus preventing viral replication; in addition, exposes the virus
to the body’s humoral immune system. Supplementation through the diet of the fungus Saccharomyces
cerevisiae would work as a fusion inhibitor drug, a mechanism of action of some antivirals
Mini Review
Important Foliar Wheat Diseases and their Management: Field Studies in Greece
DOI: 10.31031/MCDA.2021.08.000680
Wheat rusts and blotch diseases are notable diseases of wheat grown in temperate climates worldwide.
In this research, we highlight the importance of blotch diseases on wheat in Mediterranean climates like
Greece. We discuss the weather factors which influence blotch diseases of wheat development. Finally,
our analyses show that applying only Propiconazole at GS37/39 wheat growth stage, Propiconazole is
capable of inhibiting disease development with a significant effect on wheat yield
Case Report
For the Right Hemiliver Graft May Need Tissue Expander After Living Donor Liver Transplantation
Batsaikhan BE, Sergelen O, Batsaikhan B*, Bat IB1, Ganzorig B, Erdene S and Urnult G
DOI: 10.31031/SMOAJ.2021.04.000584
Hepatic venous outflow is an important for the graft survival in living donor liver
transplantation. Hepatic venous outflow obstruction generates liver failure, which may influenced due
to graft malposition, which unsized upper part of abdomen between donor and recipient. The number
of Liver Transplantation (LT) increases last few years, which is related with populating the high surgical
technology in developing country like in Mongolia. The main reason of LT is a hepatitis B virus-related
liver cirrhosis in Mongolia. Liver transplantation had started since 2011 under the supporting of
Professor Sung Gyu Lee from hepato-biliary surgery and liver transplantation of ASAN Medical Center.
Veno-Occlusive Disease (VOD), Budd-Chiari Syndrome (BCS), and Congestive Hepatopathy (CH), all of
.....
Opinion
Study on Solidification Shell Thickness of Continuous Casting Billet
Li Huicheng*, Xu Bijing, Ren Zhenhai and Zhu Fuqiang
DOI: 10.31031/AMMS.2021.06.000634
The 220mmx260mm section continuous casting billet in the company of electric
furnace was the research object in this paper. At the same time, according to the theory of
solidification shell thickness calculation formula combining design measure specific location
of the solidification shell thickness test. It can provide reliable basis for the subsequent F-EMS
optimization and basic data support for the transformation and improvement of solidification
structure of billet under soft reduction. Accurately determine the casting billet specific location
of the solidified shell thickness and solidification coefficient for optimal setting at the end of
the end of the electromagnetic stirring (F-EMS) and light pressure parameters, maximum play
F-EMS and gently press down at the end of the .....
Opinion
Clustering and Synchronization in Spin Combustion
DOI: 10.31031/AMMS.2021.06.000635
The scientific community interest to phenomena of synchronization in wildlife is
associated, first of all, with a desire to describe the functioning of living cells. Nevertheless, it
is clear that the number of objects of unanimated nature significantly exceeds the number of
living organisms (Figure 1A). Moreover, each living organism or a cell is built from unanimated
elements of the periodic table. Therefore, each manifestation of synchronization in non-living
systems is more exciting and interesting than the conventional synchronization inherent to
living cells or viruses, both in terms of the emergence of the terrestrial life on and in terms of
the greatest coverage of natural phenomena and processes (Figure 1B & 1C). Spin combustion
has been studied and detected extensively in.....
Review Article
Integrating CERVICO-Vaginal Smear into the Overall Management of Women Living with Human Immunodeficiency Virus (HIV) at the Day Hospital of the Infectious Diseases Department at the University Hospital Mohammed VI in Marrakesh
Hassan HE*, Etoughe F, Komba YB, Rateib M, Talibi ZF, Boukhani L, Rais H and Tassi N
DOI: 10.31031/IGRWH.2021.04.000578
Objective: integrated the implementation of the cervico-vaginal smear into the activity of the
infectious diseases department.
Materials and Methods: This is a prospective study conducted within the department of infectious
diseases since January 2019. The cervico-vaginal smear was proposed and carried out in women living
with HIV and followed at the day hospital.
Results: Fifty-five patients were collected. The average age was 37 years [19-65 years]. Smoking was
found in 8 patients. The average age of first sexual intercourse was 20 years with extremes ranging from
16 to 32 years. At the time of the smear, the average CD4 was 729 /mm2. A total of 14 (25.4%) patients
had a CD4 < 500. Of the 55 smears performed, the result was as follows: in 4 patients the smear was
poorly preserve.....
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