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Crimson Publishers
We at Crimson Publishing are a group of people with a combined passion for science and research, who wants...
Read More Submit ManuscriptOur Vision & Mission
Crimson is an Open-access academic publisher has a vision to establish Open Science platform that seeks to provide equal opportunity for all, share and create knowledge, and enables the scholarly world to engage in a dialogue with the science in a more effective manner. Our efficient and transparent ways of peer-review procedures provide impact metrics for articles and researchers.
Our mission is to offer quality editorial services, significant resources into technology innovation, freely accessible, discoverable scientific information, and high-quality publications. Our impact metrics provide real time view on details such as views, downloads, and citations; demographies; aggregated author impacts; how author’s profile is perceived; social buzz; career visibility; integration across platform; and functionality.
Mini Review
Micrornas, Small Gene Regulators with High Therapeutic Promise in Oncology
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Since their discovery in the mid-1990s, microRNAs (miRNAs) have captured the attention of the scientific community by their ability to post-transcriptionally and subtly regulate a large but still poorly defined set of gene targets and to control most cellular and molecular processes, making them central effectors of gene reprogramming and cell functioning under both normal and pathophysiological conditions. In this mini-review we summarize step by step the molecular mechanisms involved in miRNA biogenesis and mRNA regulation, the latter depending directly on the duration of the miRNA-mediated translational arrest and the integrity of the transcript extremities. We also discuss the nomenclature of miRNAs, the pairing rules between a miRNA and its target through the seed sequence, and the re.....
Case Report
Combination of Spinal Anesthesia and Usg-Guided Low-Dose Bilateral Infraclavicular Block in a Patient with Difficult Airway: A Rare Case Report
Hakan Akelma*, Fikret Salık, Mustafa Bıçak, İbrahim Andan, Esra Aktiz Bıçak and Akif Yıldırım
Brachial plexus blockade is commonly used in upper extremity surgery because it causes a good effec-tive intraoperative cooperation anesthesia and analgesia. When performed under USG guidance, it has high success and low complication rate. Since multiple extremity burns are present and difficult airway patients have increased blood supply in the extremities and provide long-term analgesia in burn wound healing, regional anesthesia is a good choice. In anesthesia approach, regional anesthesia technique is a good alternative to general anesthesia especially in patients with large burns accompanied by facial and neck burns. In this case, we aimed to present a case of spinal anesthesia in addition to successful low-dose bilateral infraclavicular block with USG in a patient with multiple limb b.....
Research Article
Antibiotic Resistant Zoonotic Pathogens of Bovine Mastitis and Possible Agents of Foodborne Disease
Elaine Meade, Micheal Savage, Paul Garvey, Mark Anthony Slattery and Mary Garvey*
Bovine mastitis is an inflammatory reaction of the udder or mammary gland of the cow, following colonisation with microbial pathogens. Bovine mastitis results in significant economic losses globally, resultant from a reduction in milk yield and quality in addition to treatment costs and animal culling. The disease can exist asymptomatically in its sub-clinical form however, it can quickly manifest into a clinical state where the host, pathogen and environment are all intricately linked
Opinion
Anxiety Treatment is the Natural Approach A Threat to Pharma: We Have Examined the Evidence Now You Decide
Kava has an interesting history. It has been safely consumed ceremonially in the South Pacific and other parts of the world for over 3,000 years. The earliest European knowledge of Kava dates back to the late 1700s, with the journeys of Captain Cook. Today, usage of Kava beverages in tropical climates is similar to the use of alcoholic beverages in the West. However, the plant from which the beverage is made also has useful properties for anxiety, hyperactivity, stress and restlessness.
Review Article
Clarion and Crystal-Clear Cell Acanthoma Reviewed
Clear cell acanthoma or Degos’ acanthoma or pale cell acanthoma is an exceptional, asymptomatic, cutaneous benign tumefaction of obscure etiology, emerging from epidermal keratinocytes. Solitary or multiple dome shaped lesions or well delineated nodules or plaques are frequently cogitated on distal extremities. Typically, clear cell acanthoma exhibits a “stuck on” appearance akin to seborrheic keratosis, “vascular countenance” of pyogenic granuloma, “scaling and exudation” elucidated in eczematous reactions and a “progressive margin “associated with an epithelioma. Clear cell acanthoma depicts uniform, pale keratinocytes or pale epithelial cells with abundant cytoplasm composed of excessive glycogen, centric nuclei and distinct .....
Opinion
The Identity of Space and Matter as the Basis of the Intelligence in the Physical World
The principle of identity of space and matter of Descartes returns to the matter as a Foundation for fundamental theories and making New Cartesian physics is able to generalize the theory of relativity, quantum mechanics and other branches of modern physics into a single theory of everything. Focusing on the identity of space and matter, New Cartesian physics summarizes modern physics, connecting quantum mechanics with the theory of relativity [1].
Commentary
Is the Fetus an Unborn Baby? The Moral Dilemma of Reproductive Rights: A Commentary
The purpose of this commentary is to clarify an alternative point of view in regard to the semantic differentiation that has been promoted as true fact which claims that a fetus is not a real person and as such cannot be called or treated as a baby. Advocates of the reproductive rights insist that a fetus is not a baby unless a passage of rights is earned by leaving the mother womb.
Opinion
Protein Characteristic for New Beginners
One of the branches of biotechnology is proteomics. It is an interesting field as proteins,
unlike DNA which made up of combination of 4 nucleotides, is made up of combination of
22 amino acids, where the sequence of the amino acids gives uniqueness to each protein.
In addition, the structure of the protein such as primary, secondary, tertiary and the folding
of protein into quaternary making the protein different although they may have similar
amino acid sequence. Furthermore, a functional protein may be consisting of more than one
polypeptide. Each of the amino acid has different characteristic therefore the combination
of the amino acids making protein to have different degrees of polarity. In addition, the post
translation modification of protein, such as glycosylation, lipid c.....
Mini Review
Inulin-Type Fructans in Poultry Feed
Fructans exist as a wide range of oligo- and polysaccharides in many species of bacteria, fungi, and plants [1]. They are classified into different families on the basis of their glycosidic linkages, consisting of (2→1)-linked β-D-fructofuranosyl units such as inulin, or (2→6)-linked β-D-fructofuranosyl units such as levans, or highly branched structures comprised of both (2→1)- and (2→6)-linked β-D-fructofuranosyl units such as graminans [2,3]. Among which, inulin-type fructans are perhaps by far the most widespread and researched current prebiotics.
Mini Review
Canine Leishmaniasis in Brazil
Judiele Soares, Mariana Caetano Teixeira, André Pelegrini and Clairton Marcolongo-Pereira*
Canine leishmaniasis is a vector-borne disease caused by Leishmania infantum and is transmitted by phlebotomine sand flies primarily between animals and secondarily to humans. In Brazil, approximately 3,500 cases of LV have been reported annually since 2002 affecting humans, with an average incidence of two cases per 100,000 inhabitants and a lethality rate of 5.5% in the last 12 years. The control of canine visceral leishmaniasis is based on the detection of infected animals, followed by their euthanasia and in the control of the transmitting vector. Such control, however, is a difficult task due to the great variety of reservoirs of the parasite in nature
Research Article
Assessment and Characterization of Egg Quality of South African and Indigenous Breeds
The total number of 80 eggs, 40 from local Ethiopian chickens and 40 from South African breeds poultry farm were used to determine and compare the quality of eggs of indigenous chickens purchased from market with fresh eggs of South African breeds. The important external egg quality traits evaluated in this study were egg weight, egg length, egg width, shell thickness shell weight and shape index. The in-ternal egg traits evaluated for quality in this study include yolk color, yolk width, yolk height, albumen height, yolk weight, yolk index and Hough unit. Egg weight and egg length, were significantly higher in South African breeds as compared to the indigenous ones. However, the indigenous breeds outperform the South African breeds in Yolk color, and Yolk .....
Mini Review
An Overview the Toxicology of Benzo(a)pyrene as Biomarker for Human Health: A Mini-Review
Research on food safety is attracting growing interest in the field of human health around the world.
Hazardous compounds in foodstuff come from various sources including food processing and
environmental pollution. In this mini-review, focus was on benzo[a]pyrene, an important member of
polycyclic aromatic hydrocarbons, which is mutagenic and cause changes in DNA which may increase
the cancer risk. It has been the focus of many studies because of biomarker property [1-6]. All health
organizations such as IARC, USEPA, EFSA should continuously control the benzo[a]pyrene formation,
especially in foods processed at high temperatures.
Opinion
Kombucha and Kefir are Foods of the 21st Century: A Opinion
Karina Teixeira, Magalhães-Guedes*
Kefir is a fermented milk product having slight acidic taste, carbonation, and aroma
good. The kefir beverage contains a specific mixture of microorganisms (lactic bacteria,
acetic bacteria e yeast) that reside in symbiotic manner in a kefiran polysaccharide matrix.
Kefir grains (Figure 1 & 2) can be characterized as small cauliflower florets, having a length
of 10-40mm, irregularly shaped, white to yellowish in color, having firm texture and slimy
appearance. The kefir microorganisms have a capacity to produce organic acids, antibiotics,
and numerous types of antimicrobials; these substances have a lethal effect on pathogenic
microorganisms of the body. Kefiran is an exopolysachhardie component of kefir grain that
has significant importance in human health and nutrition
Mini Review
Proteomics Exploration of Chronic Lymphocytic Leukemia
Tiara Griffen* and Steven Kornblau
Chronic Lymphocytic Leukemia (CLL) is an adult heme malignancy characterized by the presence of ma-ture-appearing CD5+ B cells in the blood, bone marrow, and secondary lymphoid organs [1]. In the United States, there will be an estimate of 20,720 new cases and 3,930 deaths according to the American Cancer Society statistics. Symptoms include swollen lymph nodes, frequent infections, and fatigue which nega-tively impacts the quality of life of people affected [1]. CLL is heterogeneous in its progression and clinical outcomes. Factors that contribute to the heterogeneity include the immunoglobulin heavy chain (IGHV) status and chromosomal aberrations [2,3]. There are two subtypes of CLL: Unmutated(U-CLL) and Mu-tated CLL(M-CLL). 40% and 60% of patients are diagnosed with unmutated and mutate.....
Research Article
Synthesis of Hydroxyapatite 2-Hydroxyethyl Methacrylate Blended Material for Dentistry
HKGKDK Hapuhinna, RD Gunaratne* and HMJC Pitawala
As a bio ceramic hydroxyapatite and its composites have applied in several biomedical applications. This research used to examine suitability of Hydroxyapatite 2-hydroxyethyl methacrylate composite for dentistry. Sri Lankan chlorapatite, ethanol and dil. acid used to synthesize hydroxyapatite by sol gel technique and then it was reinforced with polymer prior to compare and contrast it’s chemical and physical properties with human tooth and commercial dental filling material. Results show there is a close similarity between newly synthesized product and human tooth. It has credent high thermal stability, good crystalline and porous properties than the commercial product. At the end, the study concluded that the new material can be used directly as a substitution for human tooth
Short Communication
Particulate Vaccines Orchestrating Optimal Delivery and Immune Response
Amit Bansal*, Anita Sharma and Martin J D’Souza
Vaccines play a vital role in neutralizing deadly infectious diseases, and particularly particulate vaccine appears more promising due to its similar morphology with the pathogen. Particulate vaccines are effective in low doses, offset inadequate efficacy of subunit vaccine, and provide danger signals to activate the body’s immune system. It further enhances the stability of entrapped antigen and can be well tolerated in both animals and humans. For better understanding of immune response, it is important to know the physical attributes of particulate vaccine such as its size, shape and rigidity. Consequently, tailoring the physicochemical properties of particulates can alter the type and magnitude of immune response. Herein, we briefly review the impact of size, shape and .....
Review Article
A Comparative Study on the Rice Bran Stabilization Processes: A Review
Bipro N Dubey*, Drew Fitton, Samsun Nahar and Martin Howarth
Rice bran is an undervalued/underutilized by-product of rice milling, rich in protein, lipids, dietary fibers, vitamins, and minerals. It is an inexpensive source of high-quality protein, fiber and lipids to be incorporated into value-added food products. The issue with rice bran is its susceptibility to rancidity and therefore measures must be taken to stabilize the bran in order for it to be fully utilized. Due to this susceptibility to rancidity, historically the bran has either been disposed and wasted or used as low-grade animal feed. As the nutritional value of the bran has been recognized, along with its potential to add value to food products, research has been increasing in volume in order to determine the most effective methods for .....
Commentary
Development of Health Resort Casino System in Integrative Medicine
Akinori Nakanishi and Hiroshi Bando*
From a historical point of view, Integrative Medicine (IM) adds Complementary and Alternative Medicine (CAM) to traditional Western Medicine (WM) and is considered to encompass the whole [1] IM has been developed in various ways around the world [2]. There is a trend for application of CAM to many adults
Research Article
Effects of Leaf Clipping and Population Density on Green Fodder and Grain Yield in Hybrid Maize
Smallholder farmers having fragmented lands need fodder and grains simultaneously for earning food security for their families. A study was conducted in Crop Physiology and Ecology Research Field And Laboratory at Hajee Mohammad Danesh Science and Technology University, Bangladesh during the period of March to July-2013 to investigate the effect of leaf clipping and population density on fodder and grain yield in maize. Three population densities (D1=75cm×25cm, D2=60cm×20cm and D3=50cm×20cm) and three clipping treatments (C1=no clipping, C2=removal of all leaf blades below the lowermost cob and C3=removal of all leaf blades above the uppermost cob) at the silking stage were included as experimental treatments. The experiment was laid out in a two factors Randomized Co.....
Research Article
Analysis of the Biofield Energy Based Test Formulation on Vital Organ Health Specific Biomarkers Using Cell Based Assay
Vital organs dysfunction is one of the major concerns now-a-day, which results in high mortality rate in health care centers. Thus, growth and normal functioning of the vital organs is the major concern for better health. The aim of this study was to investigate the impact of the biofield energy on the test formulation and the cell line media for the function of vital organs such as bones, heart, liver, lungs, and brain using cell-based assays. Different organ-based cell lines were used in the study for testing the effects of test formulation. The test item (TI) and specific cell line media (Med) was divided into two parts; one untreated (UT-TI) and other part received the biofield energy treatment remotely by a renowned Biofield Energy Healer, Maria Isabel.....
Short Communication
Vitamin D-A Possible Natural Origin Agent for Medical Treatment of Uterine Leiomyomas in View of Safety, Cost Effectiveness Over SPRM’s-A Short Communication
Kulvinder Kochar K*, Gautam Allahbadia and Mandeep Singh
Human uterine leiomyomas (ULs) being the commonest neoplasms affecting women of reproductive age affect African American (AA) much more as compared to Caucasian (CC) women. One of the possible reasons thought is in view of higher incidence of hypovitaminosis D in this group. We have been trying to look for a permanent medical age that can be used long-term for fibroid treatment instead of the earlier selective progesterone receptor modulators(SPRM)’s of which ulipristal acetate has been recommended by the FDA but in view of its side effects like progesterone associated endometrial changes(PAECs), it can’t be used for long-term
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