Abstract

Progressive memory loss, behavioral and psychological symptoms of dementia and abolishment of daily life activities are symptoms of Alzheimer’s disease. But few studies have addressed the issues of social behavior. A series of behavior tests (include barber test, tube test, urine-making test, home cage behavioral recording and nesting tests) were used to assess the social behavior ability of the 3×Tg-AD mice. 3×Tg-AD mice couldn’t build up well-organized dominance hierarchy sequence and were impaired in nest building behavior. The impairment in social behavior in 3×Tg-AD mice provide another behavioral tool to assess the benefits of therapeutic strategies in this animal model.

Keywords:3×Tg-AD mice; Social behavior; Dominance hierarchy; Nesting behavior