1Instituto Nacional de Ciencias Neurológicas - Department of Neurodegenerative Diseases. Lima – Perú.
2Hospital “Daniel Alcides Carrión” Department of Neurology, Lima – Perú
3Instituto Nacional de Ciencias Neurológicas - Chief of the Neurogenetics Laboratory. Lima - Perú
4Physicians on Rotation, Peru
5Instituto Nacional de Ciencias Neurológicas - Chemical Engenieer at the Neurogenetics Laboratory. Lima – Perú.
6Instituto Nacional de Ciencias Neurológicas - Biologist at the Neurogenetics Laboratory. Lima – Perú
7University Hospital “José de San Martín” Buenos Aires – Argentina
*Corresponding author:Luis Torres Ramírez, Instituto Nacional de Ciencias Neurológicas- Department of Neurodegenerative Diseases, Lima – Perú
Submission: November 16, 2020 Published: December 16, 2020
ISSN 2637-7748Volume3 Issue5
Objective: To determine the prevalence of HD in five districts of Cañete Valley in order to develop a diagnosis, prevention and genetic counseling plan. Since HD is considered a hereditary disease with low prevalence, epidemiologic studies are scarce and lack genetic confirmation, which is nowadays necessary for the diagnosis of HD.
Methods: A first register of Cañete Valley inhabitants with HD was created in 1983. The population of this area has no access to health care or mass media, and the number of patients seeking for medical care is limited. Therefore, in 2004 we studied families systematically in five districts using the pedigree follow up method, which is ideal to determine the prevalence of genetic diseases and even more in communities like Cañete.
Results: We identified 30 genetically confirmed cases of HD (17 males, 13 females). The population of the five districts reached 66438 inhabitants on August4th, 2004, i.e., a minimum prevalence of 45.1 per 100 000 inhabitants. We obtained 11 pedigrees, including 1397 individuals. Twenty-four (75%) patients were newly diagnosed cases of Huntington’s disease.
Conclusion: Cañete is the second largest focus of Huntington’s disease in Latin America, and one with the highest prevalence reported worldwide
Keywords: Chorea;High prevalence; Huntington’s disease; Peru