Abstract

Yoga, aquatherapy and stretching can be used to manage mild levels of spasticity in the patients with multiple sclerosis. In more severe cases which spasms interfere with normal functions and sleep, drug therapy would be indicated. As monotherapy, Baclofen can be the first choice which stimulates the GABA receptors. Administration of Baclofen with the initial dosage of 5 to 10mg three times a day and in case of necessity, increasing the administered dosage to achieve a therapeutic response or reaching the maximum tolerated dosage which can be more than 100mg in some patients, can be a good therapeutic strategy. Nocturnal spasms can be controlled by bedtime administration of the drug. Sedation, muscle weakness and confusion can be the side effects of the Baclofen which can make its clinical usage, limited.