Abstract

The present study examines the synthesis and antibacterial activities of two newly prepared Schiff bases, bis (2-hydroxy-1-napthaldehyde hydrazine hydrate) BHNHH and bis(2-hydroxy-1-napthaldehyde m-xylene diimine) and two newly synthesized Schiff based-resins, polymethylene bis (2-hydroxy-1-napthaldehyde hydrazine hydrate) PMBHNHH and polymethylene bis(2-hydroxy-1-napthaldehyde m-xylene diimine) PMBHNMXD. All the compounds were characterized by different spectroscopic techniques and clearly determined the structure and molecular weight of compounds. The synthesized compounds were successfully used for antibacterial activity against Gram-positive and Gram-negative bacterial strains because the prepared Schiff bases and resins contain biologically active azomethine functional group, thus, the antibacterial activity was screened against Staphylococcus Aureus (Gram-positive) and Escherichia Coli (Gram-negative) by agar well diffusion method. The data confirmed that the synthesized compounds were highly active against both Gram-positive and Gram-negative bacterial strains. The broad-spectrum antibacterial activity against the reported bacteria may be due to the delocalizing of pi electrons of entering the cell wall of test bacteria, which may result in an enhancement in the lipophilic side of compounds and killing them. In summary, Schiff bases bis (2-hydroxy-1-napthaldehyde hydrazine hydrate) BHNHH and bis(2-hydroxy-1-napthaldehyde m-xylene diimine) and Schiff based resins polymethylene bis(2-hydroxy-1-napthaldehyde hydrazine hydrate) PMBHNHH and polymethylene bis(2-hydroxy-1-napthaldehyde m-xylene diimine) PMBHNMXD possessed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains and may be explored for their potential therapeutic purposes.

Keywords: Antimicrobial; Protozoan; Escherichia coli; Microorganism; Gram-positive; Bacterial strains