Abstract

Cadmium (Cd), a toxic heavy metal, ranks among the top ten environmental threats to human health, adversely affecting vital organs such as the kidneys, liver, pancreas, lungs, and testes. This study investigates the protective effects of Commiphora gileadensis (CG) sap against Cd-induced liver damage in male rats. Forty-two healthy adult male albino rats were randomly divided into seven groups: G1 (control), G2 (50mg/L cadmium chloride in drinking water), G3 and G4 (100mg/kg and 400mg/kg CG sap, respectively), G5 (50mg/L cadmium chloride + 100mg/kg CG sap), G6 (50mg/L cadmium chloride + 400mg/kg CG sap), and G7 (1% Tween 80, 1mL/rat as a vehicle). Cadmium exposure significantly reduced the antioxidant capacity and impaired liver functions. However, co-administration of CG sap markedly ameliorated these adverse effects, improving antioxidant capacity and restoring hepatic function. These findings suggest that CG sap has potential as a natural therapeutic agent to mitigate cadmium toxicity and its associated environmental hazards.

Keywords:Commiphora gileadensis; Cadmium; Liver functions; Oxidative stress; Antioxidants