Abstract

Background: The problem of dyslipidemia in diabetes is very relevant, since most of these patients die from atherosclerotic lesions and arterial thrombosis due to lipid metabolism disorders. At the same time, there is currently only invasive assessment of blood lipids, which makes their real monitoring very problematic. The hypothesis of the study was to identify the relationships between the level of cholesterol, as one of the most atherogenic LDL, and the of thermal pain sensitivity (TPS) according to the Akabane test at standard diagnostic points of the acupuncture channels (AC). The presence of such relationships provides a basis for assessing LDL by calculation method using TPS.
Methods/Design: To identify the relationships between the TPS of acupuncture channels and the concentration of cholesterol in the blood, a total of 105 patients with type 1 diabetes (11 men and 94 women) and 158 patients with type 2 diabetes (70 men and 88 women) were examined. The norm is 57 people, these are men from 26 to 35 years old and a group of 57 women without diabetes, aged 40 to 60 years. All patients underwent blood lipid biochemistry and the Akabane test with TPS assessment, which allowed for the analysis of relationships.
Result: Various methods of statistical analysis revealed reliable relationships between the TPS of certain AC and the level of cholesterol in the blood both in normal conditions and in type 1 and 2 diabetes in men and women. Moreover, these relationships mainly concerned the same AC, which reflect the work of various organs and systems usually involved in lipid metabolism, with the exception of some gender characteristics in diabetes. At the same time, the assessment of the degree of pathological disorders of cholesterol by TPS may be based on the principle of their symmetry violation, which allows for the gradation of lipid metabolism disorders by severity on new principles, by calculation based on individual or group “Training measurements”
Conclusion: Thus, based on the results of the TPS assessment at certain diagnostic points of the TCM, the proposed concept and the results obtained in this study, it becomes possible to non-invasively assess various types of lipid metabolism by calculating non-invasively using neural networks and AI on large clustered samples, which will improve the accuracy of the assessment. Further development of this technology will allow the creation of a new generation of autonomous diagnostic devices for monitoring lipid metabolism on new principles.

Keywords:Cholesterol; Diabetes mellitus type 1-2; Akabane test; Metabolic disorders; Acupuncture channels

Abbreviation: AC: Acupuncture Channels; TCM: Traditional Chinese Medicine; TPS: Thresholds of Thermal Pain Sensitivity; T1D: Diabetes Mellitus Type 1; T2D: Diabetes Mellitus Type 2; BAР: Biological Active Points