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Abstract

Open Journal of Cardiology & Heart Diseases

Valve Replacement in Pregnancy: Clinical Outcomes and Management Insights-A Case Series

Submission: March 12, 2025;Published: June 01, 2026

DOI: 10.31031/OJCHD.2025.05.000608

ISSN: 2578-0204
Volume5 Issue 2

Abstract

Background: Cardiac surgery during pregnancy presents unique challenges due to physiological changes, anticoagulation dilemmas, and fetal risks, especially in Low-and Middle-Income Countries (LMICs) where delayed referrals and limited resources complicate care.
Objective: To describe maternal and fetal outcomes of pregnant and postpartum women undergoing cardiac surgery at a tertiary care center in Pakistan, emphasizing management strategies applicable in resource-limited settings.
Methods: We report a case series of eight women who underwent cardiac surgery during or shortly after pregnancy at the Aga Khan University Hospital. Clinical presentations, operative details, and postoperative outcomes were analyzed. Cases included mitral and aortic valve replacements, redo procedures, and emergency interventions.

Results:

1. A total of 8 patients underwent cardiac surgical interventions during pregnancy or the postpartum period. The mean age was approximately 32 years (range: 26-38 years).
2. Most patients presented during pregnancy (n=5), at gestational ages ranging from 14 to 28 weeks, while 3 patients were operated in the postpartum period (ranging from 6 days to 2 weeks post-delivery). One patient had an intrauterine device in situ, and one case involved a twin pregnancy.
3. Mitral Valve Replacement (MVR) was the most commonly performed procedure (n=4 isolated MVR), while combined procedures included AVR+MVR (n=1), DVR (n=1), VSD closure+AVR (n=1), and aortic root replacement (n=1). The majority of valves used were bioprosthetic (tissue valves), with one case requiring a mechanical valve.
4. The mean Cardiopulmonary Bypass (CPB) time ranged from 100 to 235 minutes, and crossclamp time ranged from 65 to 180 minutes. Minimum intraoperative temperatures varied between 28.3 °C and 35 °C, reflecting tailored hypothermia strategies.
5. Despite the complexity of cases, including redo surgery and combined procedures, surgical interventions were successfully performed across all patients

Conclusion: Cardiac surgery during or soon after pregnancy can be successfully performed in LMICs through a structured multidisciplinary approach and adherence to evidence-based perioperative principles. This series highlights that high-quality care for critically ill pregnant cardiac patients is not only possible in resource-limited environments, but achievable to a standard of excellence.

Keywords: Pregnancy; Cardiac surgery; Valve replacement; Cardiopulmonary bypass; Maternal Outcomes; LMIC; Multidisciplinary Care

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