Abstract

The current investigation’s objective is to assess the impact of 6-Gingerol (6-GIN) and Delphidins (DELs) on the liver of an Alloxan (ALX) induced diabetic albino wistar rats. 6-Gingerol (6-GIN) and Delphidins (DELs) juice (60mg/kg body weight) were administered daily to an Alloxan (ALX) induced diabetic rats for 60 days. 6-Gingerol (6-GIN) and Delphidins (DELs) in ALX induced diabetic rats, treatment resulted in a significant (P<0.05). There was reduction in the levels of hepatic markers, lipid peroxidation markers like lipid hydro-peroxides (LOOH) and Thiobarbituric Acid Reactive Substances (TBARS), pro-inflammatory mediators like tumor necrosis factor-alpha (TNF-α), phosphorylated nuclear factor kappa-B-p65 (phospho-NF-B-p65) and cyclooxy. There was considerable (P<0.05) rise in the enzymes hexokinase, glucose-6-phosphate dehydrogenase, catalase, and other enzymatic antioxidants (CAT) and the livers of diabetic rats receiving 6-GIN+DELs treatment were shown to have increase in glutathione (GSH), glutathione peroxidase (GPx), non-enzymatic antioxidants such vitamins A, D, E and K, glutathione (GSH), and anti-apoptotic protein Bcl-x, Bcl-2. Therefore, it may be inferred that the administration of ACNs+6- GIN significantly protected the liver from the antioxidant imbalance, inflammation, and apoptosis caused by hyperglycemia and corrected the imbalance in carbohydrate metabolizing enzymes.

Keywords:Alloxan; Delphidins; Gingerol; Teplizumab; Inflammation; Peroxidation