The Author ensures that the research has been conducted responsibly and ethically with adherence to all relevant regulations. read more..
Research Centre for Health and Life Science, Coventry University, United Kingdom
*Corresponding author: Marielle Efila Endale, Department of Biomedical Sciences, Coventry University, Coventry, United Kingdom
Submission: September 17, 2024:Published: September 23, 2025
ISSN : 2578-0255Volume14 Issue 2
Cyc2 is a transmembrane c-type cytochrome central to Extracellular Electron Transfer (EET) in Acidithiobacillus ferrooxidans, an acidophilic bacterium widely used in bioleaching to target metal extraction. Despite its major functional role, and its importance as a potential target for modification, Cyc2 structure remains unresolved. This study presents a computational characterization of Cyc2 using AlphaFold3, I- TASSER, and DiffDock, revealing a fused porin–cytochrome architecture with conserved heme-binding motifs, solvent-accessible Fe²⁺ docking pockets, and aromatic π- stacking networks facilitating electron tunnelling. Electrostatic mapping confirms a negatively charged barrel lumen, supporting cation selectivity. Docking simulations with rusticyanin validate redox coupling interfaces. These findings provide mechanistic insight into microbial iron oxidation and inform future applications in bio electrochemical systems and synthetic biology.
Keywords:Cyc2; Extracellular electron transfer; Iron oxidation; AlphaFold; DiffDock; Acidophiles; Porin-cytochrome fusion; Redox modelling
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
Professor of numerous training courses in Family Medicine
Assistant Professor, Department of Electronics and Computer Science
Emeritus Professor of Physics, Kadir Has University, Turkey
Wenzhou Medical University, China
Fooyin University, Taiwan
Saglik Bilimleri University, Turkey
Vincent Pol University, Poland
National Defence University of Malaysia, Malaysia
Dogus University, Turkey
Hope College, USA
Russian Academy of Sciences, Russia
Southern Cross University, Australia
Umm Al-Qura University, Saudi Arabia
City University of New York, USA
Khalifa University of Science & Technology, United Arab Emirates
Prince of Songkla University, Thailand
Hebei Normal University, China
Alexandria University, Egypt
Indian Institute of Technology Kharagpur, India
Council for Agriculture Research and Analysis of Agri Economy (CREA), Italy
King Fahd University of Petroleum and Minerals, Saudi Arabia
Universiti Teknologi MARA, Malaysia
King Abdulaziz University, Saudi Arabia
University of Oregon, USA
University of Edinburgh, Scotland
University of Tennessee, USA
Central University of Venezuela, Venezuela
Islamic Azad University Central Tehran Branch, Iran
Tourin University, Italy
Teaching & Public Speaking, Spain
Paeditric Hospital "Giovanni XXIII", Italy
General Chemical State Laboratory , Greece
University of Nicosia, Cyprus
Universidad Miguel Hernández de Elche, Spain
Oral Roberts University, USA
Beijing Normal University, China
Howard University, USA
Edith Cowan University, Australia
Dubai Health Authority, UAE
University of Minnesota, USA
Indian Institute of Technology Kharagpur, India
Serhal Hospital, Lebanon
University of Missouri-St. Louis , USA
University of Malta, Malta
National Center for Global Health and Medicine, Japan
Molloy College, USA
Federal University of Piauí, Brazil
Krankenhaus Nordwest Hospital, Germany
Belgorod State University, Russia
Laval University, Canada
Cinvestav-Unidad Saltillo, Mexico
UPMC Hamot Neuroscience Institute, USA
Ramon Llull University, Spain
White Bear Associates, LLC, USA
Lehigh University, USA
California Southern University, USA
Institute of Solid State Physics of RAS, Russia
University of Buenos Aires, Argentina
Mansoura University, Egypt
King Saud University, Saudi Arabia
University of Coimbra, Portugal