Abstract

Infections are among the major cause of mortality in patients receiving allogeneic hemopoietic stem cell transplantation (HSCT). In the last decades, the progressive raise of Carbapenemic Resistant Enterobacteriaceae (CRE) infections was associated with a concomitant increase in terms of morbidity and mortality rates. The primary aims of our retrospective analysis were to assess the impact of SARSCOVID19 Pandemic on CRE colonization at our Transplant Program and the efficacy of new antibiotics on the 100 days and 1-yr Transplant Related Mortality in both CRE colonized and non-colonized patients. CRE colonization resulted significantly lower during SARS-COVID19 Pandemic (p<0.0001), related to the COVID-19 associated restrictions adopted at the AORN Cardarelli Hospital, in Naples. However, the outcomes of CRE colonized and non-colonized patients who underwent allogeneic Hematopoietic Stem Cell Transplant procedure were similar in terms of morbidity and mortality (p=ns).

Keywords:SARS-COVID19 pandemic; Allogeneic hemopoietic stem cell transplantation; Carbapenemic resistant Enterobacteriaceae

Abbreviations:AORN: Azienda Ospedaliera di Rilievo Nazionale; Allo-HSCT: Allogeneic Hemopoietic Stem Cell Transplantation; CRE: Carbapenemic Resistant Enterobacteriaceae; TRM: Transplant Related Mortality; GvHD: Graft Versus Host Disease; HLA: Human Leukocyte Antigens; BM: Bone Marrow; PBSC: Peripheral Blood Stem Cells; TBI: Total Body Irradiation; TBF: Thiotepa Busulphan Fludarabine; AML: Acute Myelogenous Leukemia; ALL: Acute Lymphoblastic Leukemia; PT-CY: Post-transplant Cyclophosfamide; CSA: Cyclosporine; ATG: Anti-Thymocyte Globuline; MTX: Metotrexate; MDR: Multi Drug Resistant