Abstract

Active modified cellulosic materials towards two strains (E. coli and S. aureus) and, based on Kraft pulp are described. They were synthesized by a functionalization with 1,2,3-triazole aryl compounds for antimicrobial applications, obtained through the Copper (I)-Catalyzed Alkyne-Azide 1,3-dipolar Cycloaddition (CuAAC). In this way, starting with substrates without antibacterial activities, i.e., propagylated kraft pulp and aryl azide bearing different substituent, modified lignocellulosic materials with antibacterial and/or bacteriostatic activities were obtained. From them, different mixtures were prepared, and unexpected synergistic effects in terms of antibacterial activity were observed between two kraft pulp fibres modified with different 1,2,3-triazole aryl moieties. In this way, it was possible to reach up to 100% of inhibition rates towards E. choli and 60% against S. aureus, after only 24h of contact, using substituted aryl azide with -CH₂OH or -CH₂CH₂OH and -COOEt. Furthermore, by targeting a mixture of the two different strains, the mixture between materials bearing substituents -CH₂CH₂OH and COCH₃ displayed 100% of inhibition towards E. coli and 55% against S. aureus.

Keywords:1,2,3-triazole; Kraft pulp; Synergy; Antibacterial material; Click chemistry