Abstract

Background and Objectives: Neuropathic pain represents a major neurologic complication associated with neuronal injury. It occurs when any injury, disease, or dysfunction nervous system. Nerve root mechanical compression and neuroinflammation are the two main discussed theories for the pathogenesis of neuropathic pain, especially in remained leg pain during lumbar disk herniation [LDH]. D- cycloserine [DCS] is a partial agonist of the NMDA receptors and can prevent neuropathic pain theoretically. In this study, we tested the hypothesis that DCS would reduce the postoperative neuropathic pain during the first 24 hours after single level lumbar discectomy.

Method: In the present study participants were chosen among candidates for a single level lumbar discecyomy, from March 2018 to March 2020. Randomization and data collection patients were randomly allocated into groups A and B using a numerical randomizing computer system. Each patient received an order number and took an identical capsule 2 hours before surgery containing either 250mg D- cycloserin or placebo. Visual analogue scale and morphine consumption were compared at 6 hours intervals up to 24 hours.

Result: Comparing the two groups, the D-cycloserine group showed a significant reduction in remained leg pain during the first 24 hours.

Conclusion: This study suggests that the decision to treat remained neuropathic pain after lumbar discectomies should be taken before the operation. DCS is effective to decrease remaining leg pain by the end of 24 hours in post discectomy patients.

Keywords: D-cycloserine; Discectomy; Leg pain