Aim: This study evaluated the changes in Central Macular Thickness (CMT) after Pan-Retinal Photocoagulation (PRP) in patients with Proliferative Diabetic Retinopathy (PDR).
Methods: The study involved 30 diabetic patients aged 25-80 years and followed them for 8 months. The patients underwent visual acuity assessment, anterior segment examination, intraocular pressure measurement, and fundus examination. Fundus fluorescein angiography and OCT were performed before and after PRP.
Results: a significant increase in CMT at week 2 compared to baseline, followed by a gradual decrease at week 4 after completing the treatment. The standard deviation difference between week 2 and baseline was 25.2300, with a mean of -23.2857, higher than between week 4 and baseline, which was 14.06698 with a mean of 5.78571. This suggests that PRP LASER treatment has a temporary effect on CMT.
Conclusion: The study concludes that conventional argon laser pan-retinal photocoagulation may induce acute macular morphology/thickness alterations in eyes with PDR with or without clinically significant macular oedema in the early post-laser phase, possibly due to laser-induced axonal damage.

Keywords:Macular oedema; Pan-retinal photocoagulation; Laser therapy; Diabetic macular thickness; Macular morphology; Diabetic retinopathy