Abstract

Objective: To report new discoveries made by a single investigator working solo.

Methods: The discoveries were reported. All the investigations were self-financed done over a career life. The discoveries originated in Urology but cover specialties that include Physics, Physiology, Medicine, Nephrology, Cardiovascular, respiratory medicine and Surgery.

Result: The discoveries include 2 new vascular shocks, namely Volumetric Overload Shocks (VOS) that complicate fluid therapy in hospitals. Proving a physiological law of Starling wrong and providing the correct replacement which is the hydrodynamic of the porous orifice (G) tube. Revealing many errors and misconceptions on fluid therapy and reporting its corrections. It all started with an investigation aimed at understanding a rare obscure syndrome that kills patients in Urology; the Transurethral Resection of The Prostate (TURP) syndrome. The patho-etiology of the Loin Pain Haematuria Syndrome (LPHS) was discovered revealing its link with Symptomatic Nephroptosis (SN) and reporting a new curative surgery for its treatment- the Renal Sympathetic Denervation and Nephropexy Surgery (RSD&N). A new point of technique on the surgery for cancer bladder, namely capsule sparing cystoprostadenectomy that make the surgery easier and shorter while avoiding incontinence, impotence and urethral anastomosis was reported.

Conclusion: The discoveries started in urology but extended to Physics, Physiology, Medicine, Nephrology, Cardiovascular, respiratory medicine and Surgery. It includes 2 new shocks of VOS, proving a physiological law of Starling wrong and providing the correct replacement: the hydrodynamic of the G tube. It resolves the puzzles of TURP syndrome, hyponatraemia, the acute respiratory distress syndrome and LPHS.

Keywords: Shock; Hyponatraemia; The TURP syndrome; Bladder cancer surgery

Abbreviations: HN: Hyponatraemia; VOS: Volumetric Overload Shock; VOS1: Volumetric Overload Shock Type 1; VOS2: Volumetric Overload Shock Type 2; TURP: The Transurethral Resection of the Prostate; ARDS: Acute Respiratory Distress Syndrome; MVOD/F: Multiple Vital Organ Dysfunction/Failure; HST: Hypertonic Sodium Therapy; ARF: Acute Renal Failure; NaCl: Sodium chloride; NaCo3: Sodium Bicarbonate; G tube: Porous Orifice Tube; LPHS: Loin Pain Haematuria Syndrome; SN: Symptomatic Nephroptosis; RSD&N: Renal Sympathetic Denervation and Nephropexy; IVU: Intravenous Urography; IVU-E: Intravenous Urography Erect Film; RGP: Retrograde Pyelography