Abstract

ACS (Acute coronary syndrome) is characterized by sudden development of anginal symptoms in less than 24 hours. The healthy endothelium allows normal coronary blood flow due to its anti-thrombotic properties. This property can be used to prevent ACS. Endothelial dysfunction has pivotal role in development of ACS. ATP (Adenosine tri phosphate) mismatch in the endothelial cells is the primary reason for endothelial dysfunction. Increased basal sympathetic discharge & sudden change in BMR (basal metabolic rate) produces ATP mismatch. Increased basal sympathetic discharge results from mental exhaustion, stress & is associated with fast desynchronized rhythm(beta) in EEG. Normalization of basal sympathetic discharge by reducing mental work, adequate sleep & avoidance of exposure to sudden environmental temperature change will prevent sudden BMR change & changes in ATP requirement. Both measures can prevent endothelial dysfunction & ACS. Substances like Amla (Phyllanthus emblica), and diet rich in nitric oxide also strengthens endothelium, is helpful in preventing ACS.

Keywords: Acute coronary syndrome; ATP metabolism; Basal sympathetic discharge; BMR; Endothelial dysfunction