Abstract

This study aimed to evaluate the effectiveness of Platelet-Rich Plasma (PRP) therapy in reducing periorbital wrinkles through a systematic review and meta-analysis. A comprehensive search of PubMed, Scopus, and The Cochrane Library was conducted until August 2024. The Randomized Controlled Trials (RCTs) that assessed the effects of PRP therapy on periorbital wrinkles were included. Three studies (a total of 58 participants) were included in the meta-analysis. The meta-analysis revealed no statistically significant difference between the PRP treatment group and the control group in terms of the Global Aesthetic Improvement Scale (GAIS), with a risk difference of 0.13 (95% CI: -0.27 to 0.53, p=0.52), indicating that PRP did not make a clear difference in improving patient satisfaction compared to the untreated group. However, sensitivity analysis demonstrated that after excluding the study by Heba M. Diab, the overall result showed a statistically significant difference, with a risk difference of 0.29 (95% CI: 0.02 to 0.57, p=0.037), suggesting a potential beneficial effect of PRP treatment in the absence of this study. Although the overall meta-analysis did not demonstrate a statistically significant improvement in patient satisfaction with PRP treatment compared to control, sensitivity analysis revealed a potential benefit when excluding one outlier study. These findings suggest that PRP may be effective for skin rejuvenation and periorbital wrinkle reduction in selected populations. Further well-designed studies with larger sample sizes, standardized assessment tools, and longer follow-up periods are warranted to confirm its efficacy and safety.

Keywords: Platelet-rich plasma; Periorbital wrinkle reduction; Skin rejuvenation; Crow’s feet; PRP treatment

Abbreviations: PRP: Platelet-Rich Plasma; GAIS: Global Aesthetic Improvement Scale; WSRS: Wrinkle Severity Rating Scale; MFWS: Modified Fitzpatrick Wrinkle Scale; VISIA: VISIA Complexion Analysis System; PPP: Platelet-Poor Plasma; TCA: Tri chloroacetic Acid; RCT: Randomized Controlled Trial; RoB-2: Revised Cochrane Risk of Bias Tool 2; CI: Confidence Interval; RD: Risk Difference; UV: Ultraviolet Radiation