Abstract

Collagen, an essential structural protein in the human body, is pivotal for maintaining the integrity and elasticity of skin, bones, tendons, and other connective tissues. Notably, marine-derived collagen, primarily from fish skin, scales, and bones, offers numerous health benefits and ecological advantages. This review explores the diverse biological activities of collagen hydrolysates, including Prolyl Endopeptidase (PEP) inhibitory activity, antioxidant, antimicrobial, ACE inhibitory, anticancer, hypoglycemic, antiinflammatory, immunomodulatory, joint and bone health improvement, wound healing, antiplatelet, and dermocosmetic activities. An analysis of the BIOPEP-UWM database (July 25, 2024) revealed that 71.74% of peptides contain glycine, proline, hydroxyproline, or hydroxylysine, underscoring the functional uniqueness of collagen hydrolysates. These bioactive peptides demonstrate significant potential in preventing and managing various health conditions, promoting overall well-being, and supporting sustainable production practices through marine sources.

Keywords:Marine collagen; Collagen hydrolysates; Bioactive peptides; Health benefits; Biological activities; Sustainable production

Abbreviations:ACE: Angiotensin-Converting Enzyme; DPP-IV: Dipeptidyl Peptidase IV; HUVECs: Human Umbilical Vein Endothelial Cells; IC50: Half Maximal Inhibitory Concentration; iNOS: Inducible Nitric Oxide Synthase; LHN: Low-Molecular-Weight and High-Dose Nanoemulsion; LMWCP: Low-Molecular- Weight Fish Collagen Peptides; MSCP: Milkfish Scale Collagen-Derived Peptides; NF-κB: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells; NO: Nitric Oxide; PEP: Prolyl Endopeptidase; PGE2: Prostaglandin E2; TLR: Toll-Like Receptor