Abstract

Neuroblastoma is the most common malignancy in infancy and the third most common cancer in pediatric, following the acute leukemia and central nervous system tumor, constituting approximately 7-10% of pediatric malignancy. The majority of the patients (approximately 90%) diagnosed before the age of 5 years, with peak incidence at the age of two years. However, the incidence of neuroblastoma decreasing with age and less than 5% from all cases diagnosed after the age of 10 years, its occurrence is rare during adulthood (one per 10 million cancer diagnoses per year). In addition, neuroblastoma is very rarely presented with Bone marrow involvement without identifiable primary site. We reported a young adult male patient with advanced neuroblastoma at the age of 21 with solely Bone marrow involvement without radiological identifiable primary tumor site who was died before starting him on chemotherapy treatment because of severe febrile neutropenia.

Keywords: Neuroblastoma; Young adult; Bone marrow involvement; Primary tumor; MYCN amplification

Abbreviations: g: gram; dl: deciliter; ml: milliliter; PT: Prothrobine Time; PTT: Partial Thromboblastine; CD: Cluster of Differentiation; CT: Computerized Tomography; mg: milligram; VMA: Vanillyl Mandelic Acid; HVA: Homo Vanillic Acid (HVA)