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Abstract

Novel Approaches in Cancer Study

Current Clinical Applications and Challenges of Circulating Tumor Cells

  • Open or CloseQi Zheng1, Xixi Cheng2, Haoxiang Xuan2 and Shuyang Wang1*

    1Department of Pathology, School of Basic Medical Sciences, Fudan University, 131 Dong’an Road, Shanghai 200032, Shanghai, China

    2School of Clinical Medicine, Fudan University, 130 Dong’an Road, Shanghai 200032, Shanghai, China

    *Corresponding author:Shuyang Wang, Department of Pathology, School of Basic Medical Sciences, Fudan University, 131 Dong’an Road, Shanghai 200032, Shanghai, China, Tel: +86 21-5423 7528-2122, Fax no: +86 21 5423 7596, Email: shuyangwang@fudan.edu.cn

Submission: July 31, 2020 Published: September 16, 2020

DOI: 10.31031/NACS.2020.05.000607

ISSN:2637-773X
Volume5 Issue2

Abstract

Analysis of circulating tumor cells (CTC) has received enormous attentions for its potential to obtain diverse information of tumors dynamically. Nowadays fast-developing detection technologies facilitate its biological research of tumor dissemination and clinical implications. This review is going to discuss clinical applications of CTC including prognosis and prediction of metastatic progression, surveillance of therapeutic response and identification of therapeutic targets and resistance mechanisms and to further introduce present detection technologies of CTC.

Keywords: Liquid biopsy; Circulating tumor cells; CTC

Abbreviations: CTC: Circulating Tumor Cell; CRPC: Castration-Resistant Prostate Cancer; NSCLC: Non-Small Cell Lung Cancer; CI: Confidence Interval; CDX: CTC-Derived eXplant

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