Abstract

In spite of successful basic and pre-clinical cancer research findings its translatability into clinics is significantly low. Unfortunately, most of the clinical trials in oncology are unsuccessful and lead to pharmacological drug attrition. The complex nature of cancer biology and limitations due to pre-clinical research tools makes pre-clinical cancer research prone to irreproducibility. Pharmacological development of drugs heavily relies on the published data for drug target biology and irreproducible findings are the key factor behind high failure rates of clinical trials. Consequently, there is an urgent need to revisit the pre-clinical cancer research strategies to achieve a greater clinical success.