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Abstract
Modern Approaches in Drug Designing
Comprehensive Pharmacology of Azithromycin Repurposing for COVID-19
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Open or CloseParthiba Ghosh1, Susmita Patra2, Susmita Roy1, Bipasha Mukherjee1, Pallab
Kanti Haldar2 and Asis Bala1*
1Division of Pharmacology, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, Kolkata-700114, West Bengal, India
2Phytotherapy and Pharmacology Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, West Bengal, India
*Corresponding author:Asis Bala, Division of Pharmacology, West Bengal, India
Submission: July 30, 2021; Published: August 05, 2021
ISSN : 2576-9170Volume 3 Issue 3
Abstract
The theory behind the madness of azithromycin for the treatment of COVID-19 is unclear as no significant evidences are available till date. The present study aimed to discuss about the comprehensive pharmacology of azithromycin and to explore the preclinical and clinical evidences repurposing for COVID-19. Here we reviewed briefly the current knowledge about COVID-19, considering the potential explanation for the repurpose of azithromycin for this pandemic disease condition and global crisis. Azithromycin alone or in combination with Hydroxychloroquine (HCQ) modulate the anti-inflammatory processes and decreases the susceptibility to secondary bacterial pneumonia. We highlighted potential approaches to address repurpose of azithromycin for COVID-19.
Keywords: Azithromycin; Comprehensive pharmacology; Repurposing for COVID-19; Immunomodulatory activity; Combination therapy for COVID-19
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