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Abstract

Modern Approaches in Drug Designing

An Overview of Microsponge as a Novel Tool in Drug Delivery

  • Open or CloseAbdulla Ahmed1, Mina Makram1, Mostafa Sayed1 and Dina Louis1,2*

    1 Department of Pharmaceutics and Pharmaceutical Technology, Heliopolis University for Sustainable Development, Egypt

    2 Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Egypt

    *Corresponding author:Dina Louis, Department of Pharmaceutics and Pharmaceutical Technology, Cairo University, Egypt, Kasr Eleini Street

Submission: June 18, 2018;Published: August 01, 2018

ISSN : 2576-9170
Volume2 Issue3

Abstract

Micro sponges are polymeric delivery systems consisting of porous microspheres having a size range from 5 to 300 micron. Microsponge Delivery System (MDS) is a unique technology for controlled drug delivery. The present review introduces Microsponge technology along with its synthesis, characterization, parameters and release mechanism. Wide ranges of applications are also preferred to develop drug or cosmetic products with enhanced safety and efficacy. MDS can provide increased efficacy for topically active agents with improved safety, extended product stability and improved properties in anefficient and novel manner.

Keywords: Microsponge; Drug targeting; Porous nature; Topical delivery; Solvent diffusion; Polymerization

Abbreviations: MDS: Microsponge Delivery System; TEC: Triethylcitrate; DSC: Differential Scanning Colorimetry; TLC: Thin layer chromatography; FT-IR: Fourier Transform Infra-red spectroscopy; XRD: X-ray diffraction; ePTFE: Expanded Poly Tetra Fluoro Ethylene; PGA: Poly glycolic acid; PLLA: Poly-L-lactic Acid; dsRNA: Double stranded RNA; PEI: Poly Ethylene Imine; NTPs: Nucleoside Tri Phosphates

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