Abstract

Background: Non-insulin dependent diabetes (NIDDM) usually had high risk for vascular dysfunction.

Objective: The target of this study is to measure the relationships between systemic inflammation, oxidative stress and glycemic control in non-insulin dependent diabetes.

Material and Methods: Ninety obese patients with NIDDM (54 males and 36 females). Their age mean was 49.13±5.25 year, their body mass index (BMI) ranged from 31 to 36Kg/m², and a control group included Nighty healthy volunteers, who was gender and age matched.

Results: Our study results underscores that NIDDM patients had higher significant values of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, glycosylated hemoglobin(HBA1c), Malondialdehyde (MDA), Superoxide dismutase (SOD), Inter-Cellular Adhesion Molecule (ICAM-1), Vascular Cell Adhesion Molecule (VCAM-1), E-selectin, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and Interleukin-6 (IL-6) in addition to lower significant values of the quantitative insulin-sensitivity check index (QUICKI), Glutathione (GSH) and Glutathione peroxidase (GPX) levels in comparison to controls., in addition serum levels of ICAM-1, VCAM-1, E-selectin MDA ,SOD, CRP, TNF-α and IL-6 showed a direct relationship with HOMA-IR and HBA1c. However, serum levels of GSH and GPX showed an inverse relationship with HOMA-IR and HBA1c. However, serum levels of ICAM-1, VCAM-1, E-selectin MDA, SOD, CRP, TNF-α and IL-6 showed an inverse relationship with QUICKI. However, serum levels of GSH and GPX showed a direct relationship with QUICKI.

Conclusion: There is an association between increased systemic inflammation, oxidative stress, endothelial dysfunction molecules and poor metabolic control in NIDDM.

Keywords: Endothelial dysfunction molecules; Cytokines; Metabolic control; Non-insulin dependent diabetes mellitus; Obesity; Oxidative stress

Abbreviations: NIDDM: Non-Insulin Dependent Diabetes Mellitus; BMI: Body Mass Index; QUICKI: Quantitative Insulin-Sensitivity Check Index; SOD: Superoxide Dismutase