The Author ensures that the research has been conducted responsibly and ethically with adherence to all relevant regulations. read more..
1Department of Clinical Oncology, Ac Camargo Cancer Center, Brazil
*Corresponding author:Marcos Pedro Guedes Camandaroba, Medical Oncologist, Antonio Prudente Street, São Paulo, Brazil
Submission: February 09, 2021; Published: February 24, 2021
ISSN 2637-7632Volume5 Issue4
A case of NICTH secondary to gastrointestinal stromal tumor (GIST) is described, male patient admitted to the emergency referring asthenia and drowsiness, and measured blood glucose of 20mg/dL. Patient continued to present episodes of recurrent hypoglycemia: 33/55/32mg/dL, even with continuous reposition of 10% glucose solution. Hypoglycemia can be related to several tumors, including islet cell and non-islet cell tumors. Non-islet cell tumor hypoglycemia (NICTH) is a rare and serious complication of malignancy, and its presence is usually associated with a poor prognosis. The most common cause of this type of hypoglycemia is tumor overproduction of insulin-like growth factor II (IGF-II), which stimulates the insulin receptor, leading to decreased insulin and glucagon levels. The diagnosis of NICTH is based on clinical and laboratory findings. Patients with NICTH have low serum concentrations of insulin and C-peptide during hypoglycemia. The treatment of this condition is related to the control of the underlying neoplasia. In patients who are unable to undergo invasive procedures, the use of corticosteroids is a good treatment option, leading to normalization of glycemia. Its management is of unquestionable importance to ensure the patient’s quality of life. A review of the literature on epidemiology, diagnosis and treatment of this complication follows.
Keywords:Hypoglicemia; Paraneoplastic endocrine syndromes; Gastrointestinal stromal tumors
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
Professor of numerous training courses in Family Medicine
Assistant Professor, Department of Electronics and Computer Science
Wenzhou Medical University, China
Fooyin University, Taiwan
Saglik Bilimleri University, Turkey
Vincent Pol University, Poland
National Defence University of Malaysia, Malaysia
Dogus University, Turkey
Hope College, USA
Russian Academy of Sciences, Russia
Southern Cross University, Australia
Umm Al-Qura University, Saudi Arabia
City University of New York, USA
Khalifa University of Science & Technology, United Arab Emirates
Hebei Normal University, China
Alexandria University, Egypt
Indian Institute of Technology Kharagpur, India
Council for Agriculture Research and Analysis of Agri Economy (CREA), Italy
King Fahd University of Petroleum and Minerals, Saudi Arabia
King Abdulaziz University, Saudi Arabia
University of Oregon, USA
University of Edinburgh, Scotland
University of Tennessee, USA
Central University of Venezuela, Venezuela
Islamic Azad University Central Tehran Branch, Iran
Tourin University, Italy
Teaching & Public Speaking, Spain
Paeditric Hospital "Giovanni XXIII", Italy
University of Nicosia, Cyprus
Universidad Miguel Hernández de Elche, Spain
Oral Roberts University, USA
Beijing Normal University, China
Howard University, USA
Edith Cowan University, Australia
Dubai Health Authority, UAE
University of Minnesota, USA
Indian Institute of Technology Kharagpur, India
Serhal Hospital, Lebanon
University of Malta, Malta
National Center for Global Health and Medicine, Japan
Molloy College, USA
Federal University of Piauí, Brazil
Krankenhaus Nordwest Hospital, Germany
Laval University, Canada
Cinvestav-Unidad Saltillo, Mexico
UPMC Hamot Neuroscience Institute, USA
Ramon Llull University, Spain
White Bear Associates, LLC, USA
Lehigh University, USA
California Southern University, USA
Institute of Solid State Physics of RAS, Russia
University of Buenos Aires, Argentina
Mansoura University, Egypt
King Saud University, Saudi Arabia
University of Coimbra, Portugal