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Abstract
Gastroenterology Medicine & Research
Evaluation of 68Ga-labeled TPP-1: A Targeted PDL1 Probe for PET Imaging of Colorectal Cancer
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Open or CloseXiaojiao Wang1, Beibei Zhang2, Xiao Li1* and Danni Li1*
1Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, China
2Shenzhen Second People’s Hospital, Shenzhen, China
*Corresponding author:Danni Li and Xiao Li, Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, China
Submission: February 05, 2021; Published: February 15, 2021
ISSN 2637-7632Volume5 Issue4
Abstract
Although PD-1/PD-L1 immuno-blocking therapy (IBT) has improved the prognosis of patients with gastrointestinal tumors to some extent, not all patients respond to IBT. Recent studies have shown that PD-L1 antigen expression in tumors is prognostic marker of response to PD-1/PD-L1 IBT. Here, 68Ga-TPP-1 was developed for specific and non-invasive imaging of PD-L1 expression in mouse models of colorectal cancer. Positron emission tomography (PET) and immunohistochemistry (IHC) results confirmed the highly specific targeting of 68Ga-TPP-1 in PD-L1 expressing colorectal cancer mice.
Keywords: Immuno-PET imaging; Colorectal cancer; PD-L1; Ga-68
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