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Abstract

Gerontology & Geriatrics Studies

Cerebral Angiogenesis and Neurogenesis in The Treatment of Ischemic Stroke in Elderly and Geriatric Patients

  • Open or CloseIvan V. Maksimovich*

    Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Russia

    *Corresponding author:Ivan V. Maksimovich, Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Russia

Submission: September 23, 2024;Published: October 01, 2024

DOI: 10.31031/GGS.2024.09.000706

ISSN 2578-0093
Volume 9 Issue 2

Abstract

Aim: The research is devoted to the clinical application of transcatheter intracerebral Laser Photo Bio Modulation Therapy (PBMT) for angiogenesis stimulation, cerebral collateral blood supply restoration, neurogenesis stimulation, cerebral tissues regeneration in ischemic stroke treatment.
Methods: 953 patients aged 30-80 (average age 74.6) with ischemic stroke were examined. There were 696 men (73.03%) 257 women (26.97%).
Test group: 610 (64.01%) patients underwent transcatheter intracerebral laser PBMT, of whom 354 (58.04%) had small focal stroke, 189 (30.98%) had medium focal stroke and 67 (10.98%) had macrofocal stroke.
Control group: 343 (35.99%) patients underwent conservative treatment, of whom 256 (74.64%) had small focal stroke, 43 (12.54%) had medium focal stroke and 44 (12.82%) had macrofocal stroke.

Results

Test group: Angiogenesis stimulation, cerebral collateral blood supply restoration, neurogenesis stimulation and cerebral regenerative processes were achieved in all 610 cases regardless of the patients’ age. Good clinical result was obtained in 313 (88.42%) patients with small focal strokes, in 114 (60.32%) patients with medium focal strokes, in 14 (20.90%) patients with macrofocal strokes. Satisfactory clinical result was obtained in 36 (10.17%) patients with small focal strokes, in 48 (25.39%) patients with medium focal strokes, in 27 (40.30%) patients with macrofocal strokes.
Control group: Good clinical result was obtained in 51 (19.92%) patients with small focal strokes; patients with medium focal and macrofocal strokes showed no good result. Satisfactory clinical results were obtained in 63 patients (24.61%) with small focal strokes and in 8 patients (18.60%) with medium focal strokes. No satisfactory results were obtained in patients with macrofocal strokes.
Conclusion: Angiogenesis and neurogenesis are important directions in ischemic stroke treatment. Transcatheter intracerebral laser PBMT stimulates these processes and is an effective, pathogenetically substantiated method for ischemic stroke treatment. The method normalizes cerebral blood supply, causes tissue regeneration, which leads to the restoration of daily life, cognitive and mental functions in young as well as in elderly and geriatric patients.

Keywords:Ischemic stroke; Therapeutic targets; Transcatheter intracerebral laser photobiomodulation therapy; PBMT; Angiogenesis; Neurogenesis; Regeneration

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