Abstract

The plasminogen activator inhibitor type-1 (PAI-1) acts negatively on the fibrinolysis process, in wich the plasminogen changes to plasmina, interrupting the fibrinolysis and favoring the thrombosis. The thrombosis is associated with recurrent spontaneous abortion (RSA), and the thromboembolism (TE), and is the main cause of maternal death during pregnancy and postpartum. The PAI-1 especiately the polymorphism 4G/5G has a relation with the increased risk of venous thrombosis associated with protein deficiency S or FVL Leiden factor. It is advisable to evaluate the existence of thrombophilia in patients with a family history of ischemic manifestations, as they are related to obstetric complications.

Keywords: Recurrent spontaneous abortion; PAI-1; Thrombophilia; Thromboembolism; Venous thromboembolism; Polymorphism