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Abstract
Orthopedic Research Online Journal
Osteoarthritis Current Understanding
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Open or Close Abdul Ahad Khan*
Amina Hospital, Ajman, UAE
*Corresponding author: Abdul Ahad Khan, Amina Hospital, Ajman, UAE
Submission: March 14, 2018;Published: March 21, 2018
ISSN: 2576-8875Volume2 Issue2
Abstract
Osteoarthritis has long been considered a ‘wear and tear’ disease leading to loss of cartilage. Progress in molecular biology in the 1990s has profoundly modified this paradigm. The discovery that many soluble mediators such as cytokines or prostaglandins can increase the production of matrix metalloproteinases by chondrocytes led to the first steps of an ‘’inflammatory’’ theory. Recent experimental data have shown that subchondral bone may have a substantial role in the OA process, as a mechanical damper, as well as a source of inflammatory mediators implicated in the OA pain process and in the degradation of deep layer of cartilage.
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