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Abstract
Open Journal of Cardiology & Heart Diseases
On the Mechanism of Depolarisation and Repolarisation in the Sino-Atrial Node
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Open or Close Mark IM Noble*
Department of Medicine and Therapeutics, University of Aberdeen, UK
*Corresponding author: Mark IM Noble, Department of Medicine and Therapeutics, Cardiovascular Medicine, University of Aberdeen, Aberdeen, UK
Submission: January 12, 2018; Published: January 25, 2018
ISSN: 2578-0204Volume1 Issue2
Abstract
In 16 traces of spontaneous activity of sinus node pacemaker cells of various species from mouse to man, the charge change during repolarisation was between 3 and 8 times (mostly between 3 and 4 times) that recorded during the pacemaker current (“funny current”, If). This finding is incompatible with the necessity for a steady state of ionic movement in and out of the cell - the ionic balance; there is a deficit of outward positive ion movement sufficient to complete repolarisation. It is postulated that the deficit is solved by generation of electrical energy in the form of electrons by oxidative phosphorylation of mitochondria.
Keywords: Heart; Cardiac pacemaker; Funny current; Ionic balance
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