1Singapore Phenome Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
2Health Services and Systems Research, Duke-NUS Medical School Singapore, Singapore
*Corresponding author: Sean Pin Ng, TANG Xingyu, Singapore Phenome Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Submission: June 26, 2018; Published: July 25, 2018
ISSN 2578-0247Volume2 Issue2
This article is to introduce the procedure of untargetedultra-performance liquid chromatography-mass spectrometry(UPLC-MS) downstream data processing and statistical analysis, developed and optimized in Singapore Phenome Centre (SPC). The procedure is illustrated by a pilot study on cognitive impairment.
Keywords: Feature filtration; Normalization; OPLS-DA; PCA; Quality control; Untargeted UPLC-MS