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Abstract

Open Access Biostatistics & Bioinformatics

Untargeted UPLC-MS Downstream Data Processing and Statistical Analysis - Illustrated by a Pilot Study on Cognitive Impairment

  • Open or Close TANG Xingyu1*, KOH Woon-Puay2, NG Sean Pin1*

    1Singapore Phenome Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

    2Health Services and Systems Research, Duke-NUS Medical School Singapore, Singapore

    *Corresponding author: Sean Pin Ng, TANG Xingyu, Singapore Phenome Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Submission: June 26, 2018; Published: July 25, 2018

DOI: 10.31031/OABB.2018.02.000531

ISSN 2578-0247
Volume2 Issue2

Abstract

This article is to introduce the procedure of untargetedultra-performance liquid chromatography-mass spectrometry(UPLC-MS) downstream data processing and statistical analysis, developed and optimized in Singapore Phenome Centre (SPC). The procedure is illustrated by a pilot study on cognitive impairment.

Keywords: Feature filtration; Normalization; OPLS-DA; PCA; Quality control; Untargeted UPLC-MS

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