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Abstract

Novel Research in Sciences

Effects of Sibutramine Treatment on Serum Lipoproteins and Il-6 Levels in Rats Fed with High Protein Diet

  • Open or CloseMaria Trapali*

    Department of Biomedical Sciences, Greece

    *Corresponding author: Maria Trapali, Department of Biomedical Sciences, Greece

Submission: June 19, 2021Published: June 25, 2021

Abstract

The aim of the study was to explore the effects of macronutrients and Sibutramine(S) on serum IL-6 and lipoprotein levels in rats fed with standard laboratory diet (SD) and High protein diet (HPD). Two groups of 21 male Wistar rats consumed SD or HPD for 13 weeks. In the last 3 weeks each of them was divided into 3 subgroups received vehicle, Sibutramine 5 or 10mg/kg. Serum lipoproteins and IL-6 were assayed. Serum HDL-CHOL was lower in the SDS0 compared to HPDS0group, in the SDS5 compared to HPDS5, in HPDS10 compared to HPDS5. Sibutramine administration did not affect serum IL - 6, HDL or LDL in any diet group at any dose.

Keywords: IL-6; Sibutramine; High-protein diet

Abbreviations: SD: Standard laboratory Diet; HPD: High Protein Diet; S: Sibutramine;

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