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Abstract
Novel Research in Sciences
The Proliferation and the Terminal Differentiation of Progenitor Stem Cells Determine the Success of Wound Healing. Likewise, the Proliferation and the Terminal Differentiation of Cancer Stem Cells Determine the Success of Cancer Therapy
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Open or CloseLiau MC* and Baker LL
Department of CDA Therapeutics, USA
*Corresponding author:Liau MC, Department of CDA Therapeutics, USA
Submission: March 08, 2021;Published: March 09, 2021
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Abstract
Wound healing and the evolution of cancer are closely related to involve progenitor stem cells (PSCs) as the critical common elements. PSCs and cancer stem cells (CSCs) are very much alike on cell features and biological missions. It is very likely that CSCs are originated from PSCs. In the transition TET-1 enzyme is silenced, which marks the critical difference between PSCs and CSCs [1,2]. PSCs are still able to carry out differentiation programs, relying on TET-1 enzyme to achieve DNA hypomethylation required for the cell to undergo terminal differentiation (TD) [3].
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