Abstract

Background and Objectives: Satureia hortensis (summer savory) from Lamiaceae (labiatae) family is valuable by its rich existence of essential oil. Taking in account several pharmacol ogical effect of mentioned genus essential oil’s compounds, it was investigated the Armenian flora Satureja hortensis essential oil chemical composition, obtained pharmaceutical forms and studied antimicrobial, anti-inflammatory antinociceptive and wound healing activities. \r\nMaterial and Methods: \r\nSatureia hortensis essential oil chemical composition analysis was carried out by gas chromatography-mass spectroscopy (GC-MS) method. Antimicrobial effects of the essential oil were studied by disc-diffusion assay. The evaluation indicator for antimicrobial activity was the inhibited zone diameter in the Petri plates. The mentioned oil antinociceptive and anti-inflammatory activities have been estimated correspondingly in the «tail-flick» and xylene induced acute ears edema test of rats’ experimental model. The rats were pretreated with 20, 50 and 100 mg/kg doses. The regeneration ability of the ointment from essential oil of Savory leaves under the condition of thermal burn has been studied.\r\nResults\r\ nData obtained according to chemical analysis by GC-MS method have shown that Satureja hortensis essential oil contains 13 components. Carvacrol (42.262%) and γ-terpinene (32.020%) characterized by high antimicrobial activity were found to be the main components in the essential oil. The results of the disk-diffusion method showed strong antimicrobial activity on the growth of pathogenic bacterial and fungal strains such as Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538-P, Pseudomonas aeruginosa ATCC 2549, Bacillus subtilis ATCC 6633 and Candida albicans ATCC 10231․\r\n. The obtained results evident that the highest antinociceptive activity of the mentioned oil registered in the dose 50 mg/kg for 62.95%.