Abstract

Cannabinoids, the active constituents of Cannabis sativa, replicate the effects of endogenous cannabinoids by engaging specific cannabinoid receptors, notably the CB1 receptor predominantly located in the central nervous system and the CB2 receptor primarily associated with immune function. Delta-9-tetrahydrocannabinol, the principal bioactive cannabinoid in this plant has been approved as a prescription medication for managing chemotherapy-induced nausea and vomiting as well as anorexia. Furthermore, cannabinoids may provide relief in cancer-related pain due to a potential synergistic effect with opioid analgesics. They have also demonstrated efficacy in alleviating peripheral neuropathy resulting from chemotherapy. While cannabinoids possess a favorable safety profile, their therapeutic application is often constrained by their psychoactive properties and limited bioavailability. This review aimed to explore the application of medicinal cannabis in alleviating symptoms experienced by cancer patients.

Keywords: Cannabinoids; Cannabis sativa; Cancer-related symptoms; Cancer patient care