Abstract

Aggressive brain tumor i.e. Glioblastoma multiforme has been known to be having poor prognosis with maximum therapeutic trial. A number of studies have already been published showing improvement in survival after maximal safe resection followed by adjuvant CCRT in terms of improving survival in years but the overall prognosis of glioblastoma multiforme is dismal. In this case, a lady un-fortunately had not gone through complete resection of the tumor because of the tumor location then she received adjuvant treatment with concurrent chemo-radiation with temozolomide followed by continuation of temozolomide alone for a total of 17 cycles after she had disease progression then she was switched to bevacizumab. So far, she has received 2 weekly total of more than 35 cycles with stable disease status without toxicity. Up till now, she has passed more than 5 years without any deterioration in her performance score. Despite the fact that GBM has a dismal prognosis and maximum survival is 3 years. In the future, more research will be required to determine the role of other VEGF inhibitors in recurrent settings as well as upfront settings. This case gives a stimulus to make some more effort to improve survival for future cases of GBM.