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Abstract

Novel Approaches in Cancer Study

Targeting Bombesin Peptide Receptors for Cancer Imaging: Perspective in Prostate, Lung and Breast Cancer

Submission: August 25, 2020 Published: October 09, 2020

DOI: 10.31031/NACS.2020.05.000611

ISSN:2637-773X
Volume5 Issue3

Abstract

Peptides-coupled imaging agents are emerging as a new tool for early diagnosis with low adverse effects. Peptide-receptor based radiolabeled complex with good affinity to target specific receptors in cancers are required for imaging and quantification. Receptor mediated targeting of tumors for diagnosis, therapy or both is an encouraging approach and has increased remarkably over past 10-15 years. The attainment of these approaches related to selection of specific receptor for certain cancer type and their binding to the specific ligand. Receptor targeting radiopharmaceuticals are easy to synthesize and being small molecules, they exhibit excellent permeability, low immunogenicity, high specificity and minimum side effects. Gastrin-releasing three mammalian bombesin peptide receptors have shown great potential for cancer targeting because of their overexpression in various human malignancies. This review discusses the recent advances of bombesin receptors as potential targets for diagnosis using radiolabel bombesin analogues in prostate, lung, and breast cancer.

Keywords: Bombesin; Cancer; Gastrin-releasing peptide; Prostate cancer; Breast cancer; Lung cancer

Abbreviations: BN: Bombesin; CT:Computed Tomography; 64Cu: Copper-64; 18F: Fluorine-18; GRPR: Gastrin-Releasing Peptide Receptor; 68Ga: Gallium-68;HER 2: Human Epidermal Growth Factor Receptor Type 2; 111In: Indium-111; 177Lu: Lutetium-177; NMB:Neuromedin B Receptor; PET: Positron Emission Tomography; PSMA: Prostate-Specific Membrane Antigen; SPECT: Single Photon Emission Computed Tomography; SUV Max: Maximum Standardized Uptake Value; 99mTc: Technetium-99m; 90Y: Yttrium-90

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