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Abstract

Novel Approaches in Cancer Study

Methods, Challenges and Future Directions of Radiogenomics

  • Open or CloseLehui Du1, Hui Zheng2* and Baolin Qu1*

    1Department of Radiation Oncology, China

    2Tianjia Genomes Tech CO., LTD., China

    *Corresponding author:Baolin Qu, Department of Radiation Oncology, Chinese PLA General Hospital, China and Hui Zheng, Tianjia Genomes Tech CO., LTD., China

Submission: April 13, 2020 Published: April 29, 2020

DOI: 10.31031/NACS.2020.04.000592

ISSN:2637-773X
Volume4 Issue4

Abstract

Tissue response to the radiation is a complex pathophysiological process and is an inherited polygenic trait. Aim of the Radiogenomics studies is to discover related genetic variants that confer tumor or nontumor tissue radio sensitivity as the target of radio-sensitizing and/or radio-protective agents and to identify specific genetic markers for prognosis or risk prediction. The methods for radiogenomics studies include candidate gene approaches, genome-wide association studies, Next-Generation Sequencing (NGS), epigenetic study, and other methods. The future direction of radiogenomics should be the development of the polygenic risk scores that are incorporated into end point-specific clinical models/nomograms.

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