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Abstract

Novel Approaches in Cancer Study

Release of Inorganic Phosphate into the Tumor Environment: Possible Roles of Ecto- Nucleotidases and Ecto-Phosphatases

  • Open or CloseMarco Antonio Lacerda-Abreu1,2* and José Roberto Meyer-Fernandes1,2*

    1Institute of Medical Biochemistry Leopoldo de Meis, Brazil

    2National Institute of Science and Technology in Structural Biology and Bioimaging, Brazil

    *Corresponding author: Marco Antonio Lacerda-Abreu and José Roberto Meyer- Fernandes, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil

Submission: October 21, 2019; Published: October 29, 2019

DOI: 10.31031/NACS.2019.03.000568

ISSN:2637-773X
Volume3 Issue4

Abstract

Inorganic phosphate (Pi) is essential for several biochemical reaction. Serum Pi is maintained at relatively narrow range concentrations, between 0.7 and 1.55mM. Tumor microenvironment presents a high Pi concentration (1.8±0.2mM Pi) and this could be associated wi the rapid growth in the “Growth Rate Hypothesis”. Several studies have identified high expression of Pi transporters in various tumor tissues. Similarly, ecto-enzymes (like ecto-nucleotidases or ecto- phosphates) act by dephosphorylating phosphosubstrates in the extracellular environment, and its high expression has been observed in various types of cancer. Little is known about the function of these ecto-enzymes on Pi releasing and accumulation in the tumor environment. Therefore, the purpose of this study is to correlate a possible contribution of the Pi release in the tumor microenvironment by ecto-nucleotidases and ecto-phosphatases, concomitant to the regulation of Pi extracellular pool by specific Pi transporters, associating it to the tumorigenesis.

Keywords: Ecto-nucleotidases; Ecto-phosphatases; Pi transporters;Pi release; Cancer

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