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Abstract

Novel Approaches in Cancer Study

Are We Still Missing the Target in Trying to Prevent and Treat Human Cancers?

  • Open or CloseJames E Trosko*

    Department of Pediatrics/Human Development, USA

    *Corresponding author: James E Trosko, Department of Pediatrics/Human Development, East Lansing, Michigan 48824, USA

Submission: July 12, 2019; Published: August 26, 2019

DOI: 10.31031/NACS.2018.03.000556

ISSN:2637-773X
Volume3 Issue1

Abstract

Solving the problem of preventing or treating cancers is still a major problem. While much is known about those multi-disciplinary contributors to the initiation, promotion and progression phases of human cancers, major hurdles to efficacious prevention and treatment involve, while recognizing that there are many known factors that can influence human carcinogenesis, little integration of this knowledge has been used. This brief “Opinion” paper hypothesizes that, by recognizing the multi-stage, multi-mechanism process of carcinogenesis, the roles of organ-specific adult stem cells as the “targets for two types of “cancer stem cells”, and new strategies for nutritional /dietary intervention, could help in the prevention of early susceptibility for cancers later in life, as well as for treatment for the two very different “cancer stem cells”. “In this light, a new perspective for therapeutic intervention by directing differentiation and restoring communications between cancer cells is certainly relevant, and the example of gap junctions is illuminating” [1].

Keywords: Stem cell hypothesis of cancer; Human adult stem cells; Cancer stem cells; Multi-stage; Multi- mechanism hypothesis of carcinogenesis

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