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Abstract
Novel Approaches in Cancer Study
HDAC4 and HDAC7 Promote Breast and Ovarian Cancer Cell Migration by Regulating Emt Relative Marker
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Open or Close Shuangping Liu1, Hao Sheng2, Jiao Liu2, Changliang Shan3* and Shuai Zhang4*
1Department of Pathology, Medical School,Dalian University, Dalian, Liaoning 116622, China.
2Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong 510632, China.
3College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
4School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China.
*Corresponding author: Shuai Zhang, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China Email: souaizhang@tjutcm.edu.cn
Submission: January 14, 2019;Published: January 23, 2019
ISSN:2637-773XVolume2 Issue1
Abstract
Breast and ovarian cancer have been remained as a highly malignant tumor among women, posing a serious threat to women health worldwide. In this study, we were aimed to investigate the underlying mechanism of breast and ovarian cancer cell migration. Wound healing assay showed that MDA-MB-231and C13* have higher migration potential compare with MCF-7 and OV2078 cells, as well as regulated epithelial-mesenchymal transition (EMT) marker. We found that HDAC4 and HADC7 mRNA are up regulated in MDA-MB-231 and C13* cells. Moreover, target HDAC4 and HDAC7 by TSA or shRNA block MDA-MB-231and C13* migration. These results reveal a new link between HDACs and EMT in the regulation of breast and ovarian cancer migration.
Keywords: Histone deacetylases (HDACs); Epithelial-mesenchymal transition (EMT); Migration
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