Abstract

Oxidative stress and inflammatory damage act the most severe roles in neurodegenerative disorder and represent a target for treatment. Brain cells are especially prone to oxidative stress in neurodegenerative diseases, which leads to neuronal death. The formulation of drug targeting in the brain is a difficult task for scientists due to the limited penetration of the drugs in brain endothelial cells where the Blood Brain Barrier (BBB) is the major obstruction. Nanotechnology approach provides the best answer to brain targeting. This mini review focuses on the nanotechnology approaches of the compounds which scavenge oxidative stress-induced products like Reactive Oxygen Species (ROS) which are associated with different neurodegenerative disorder worldwide

Keywords:Neurodegenerative diseases; Oxidative stress; Nanoparticle; Reactive oxygen species; Blood brain barrier