The Author ensures that the research has been conducted responsibly and ethically with adherence to all relevant regulations. read more..
Department of Biochemistry, Periyar University, India
*Corresponding author: M Krishnaveni, Assistant Professor, Department of Biochemistry, Periyar University, Salem-636 011, India
Submission: September 18, 2017; Published: October 11, 2017
ISSN: 2576-9170Volume1 Issue1
Cyclin dependent kinases are proline directed serine / threonine protein kinases comprising of catalytic CDK subunit and active cyclin subunit. Till now around 25 different cyclins and 13 different cyclin dependent kinases are reported but only 7 CDK’s play a major role in the progression of cell cycle. Usually throughout cell cycle, cyclin levels vary and CDK remains constant. Complete activation of cyclin dependent kinases takes place by the phosphorylation of threonine residue close to kinase active site. Cyclin dependent kinases phosphorylate various substrates that are required for the progression of cell cycle. The eukaryotic cell growth and cell division are regulated at late G1, G2/M, metaphase to anaphase transition (check points). The first two check points are controlled by cyclin dependent kinases and are specific for each phase like CDK 4, 6 controls late G1 and S phase by CDK2 and CDK 1, while G2/M and last by anaphase promoting complex. Cyclin D interaction with CDK 4 regulates S phase initially, apart from this CDK 4/6 regulation at transcriptional level controls late G1 phase. Loss of cell cycle control, hyper-activation of cyclin dependent kinases due to mutation causes cancer. So, inhibitions of cyclin dependent kinases are targets in cancer therapy. The inhibitors of cyclin dependent kinases are ATP-competitive, ATP-noncompetitive (including some small mimetic peptides for p21, p27 and p57), Allosteric inhibitors. Let us have a look on some of the inhibitors in this review.
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
Professor of numerous training courses in Family Medicine
Assistant Professor, Department of Electronics and Computer Science
Emeritus Professor of Physics, Kadir Has University, Turkey
Wenzhou Medical University, China
Fooyin University, Taiwan
Saglik Bilimleri University, Turkey
Vincent Pol University, Poland
National Defence University of Malaysia, Malaysia
Dogus University, Turkey
Hope College, USA
Russian Academy of Sciences, Russia
Southern Cross University, Australia
Umm Al-Qura University, Saudi Arabia
City University of New York, USA
Khalifa University of Science & Technology, United Arab Emirates
Hebei Normal University, China
Alexandria University, Egypt
Indian Institute of Technology Kharagpur, India
Council for Agriculture Research and Analysis of Agri Economy (CREA), Italy
King Fahd University of Petroleum and Minerals, Saudi Arabia
King Abdulaziz University, Saudi Arabia
University of Oregon, USA
University of Edinburgh, Scotland
University of Tennessee, USA
Central University of Venezuela, Venezuela
Islamic Azad University Central Tehran Branch, Iran
Tourin University, Italy
Teaching & Public Speaking, Spain
Paeditric Hospital "Giovanni XXIII", Italy
University of Nicosia, Cyprus
Universidad Miguel Hernández de Elche, Spain
Oral Roberts University, USA
Beijing Normal University, China
Howard University, USA
Edith Cowan University, Australia
Dubai Health Authority, UAE
University of Minnesota, USA
Indian Institute of Technology Kharagpur, India
Serhal Hospital, Lebanon
University of Malta, Malta
National Center for Global Health and Medicine, Japan
Molloy College, USA
Federal University of Piauí, Brazil
Krankenhaus Nordwest Hospital, Germany
Laval University, Canada
Cinvestav-Unidad Saltillo, Mexico
UPMC Hamot Neuroscience Institute, USA
Ramon Llull University, Spain
White Bear Associates, LLC, USA
Lehigh University, USA
California Southern University, USA
Institute of Solid State Physics of RAS, Russia
University of Buenos Aires, Argentina
Mansoura University, Egypt
King Saud University, Saudi Arabia
University of Coimbra, Portugal