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Abstract

Interventions in Obesity & Diabetes

Dietary Supplementation in Metabòlic Acidosis in Patients with Liver Dysfunction

  • Open or CloseJoanna Michalina Jurek*

    Department of Medicine and Surgery, GEMMAIR Research Group, Tarragona Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Rovira i Virgili University (URV), Spain

    *Corresponding author:Joanna Michalina Jurek, Department of Medicine and Surgery, GEMMAIR Research Group, Tarragona Joan XXIII University Hospital, Pere Virgili Health Research Institute (IISPV), Rovira i Virgili University (URV), C/ Dr. Mallafré Guasch, 4, 43005 Tarragona, Spain

Submission: September 04, 2024;Published: September 25, 2024

DOI: 10.31031/IOD.2024.06.000647

ISSN : 2578-0263
Volume6 Issue5

Abstract

The liver plays a crucial role in maintaining acid-base equilibrium, an essential process for overall metabolic homeostasis. This review explores the liver’s involvement in acid-base regulation, focusing on mechanisms like lactic acid metabolism, urea production, ketogenesis, and albumin homeostasis. Liver dysfunction, such as cirrhosis or acute liver failure, can lead to metabolic acidosis, exacerbated by conditions like hyponatremia, hyperchloremic metabolic acidosis, and lactic acidosis. Additionally, dietary habits, particularly high-protein and low-carbohydrate diets, can further disrupt acid-base balance, influencing conditions like Non-Alcoholic Fatty Liver Disease (NAFLD). Dietary interventions and supplementation offer potential strategies for managing metabolic acidosis in patients with liver dysfunction. Supplements such as carnitine, branched-chain amino acids, sodium bicarbonate, magnesium, omega-3 fatty acids, and alpha-lipoic acid may help restore acid-base homeostasis and improve liver function. Furthermore, dietary patterns like the Mediterranean diet, low-protein diet, and alkaline diet can mitigate acid-base disturbances by reducing acid load and supporting metabolic health.

The review emphasizes the need for personalized dietary recommendations and supplementation strategies in managing metabolic acidosis in liver disease patients, particularly those with NAFLD. By addressing both nutritional and metabolic factors, these interventions can potentially improve patient outcomes and prevent the progression of liver-related complications.

Keywords:Dietary supplementation; Nutrition; Acidosis; Metabolism; Liver dysfunction

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