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Abstract
Interventions in Obesity & Diabetes
Immune System Response to Weight Loss among Obese Saudi Non-Alcoholic Fatty Liver Disease Subjects
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Open or CloseFadwah M Al Sharif*
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Saudi Arabia
*Corresponding author:Fadwah M Al Sharif, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Submission: April 25, 2020Published: May 05, 2020
ISSN : 2578-0263Volume4 Issue1
Abstract
Background: Globally, non-alcoholic fatty liver disease (NAFLD) is medical problem. Obesity is related to NAFLD. However, obesity has been linked to dysfunctional immune system.
Objective: The main target of this study was to measure the immunological parameters after weight loss among NAFLD obese Saudi subjects.
Material and Methods: Ninety obese Saudi individuals with NAFLD enrolled in our study, the range of the participants’ age was 42-53 years, where the range of BMI was 32-36 kg/m2. Participants were randomly assigned in group (A) received weight reducing program for 3 months, where group (B) received no intervention.
Results: There was a 32.7%, 31.8%, 32.1%, 21.9%, 33.7%, 6%, 12% and 24.3% reduced mean values of BMI, WBCs, monocytes, total neutrophil count, CD3, CD4, CD8 and CD4/CD8 ratio in group (A) respectively. While, there was a 3.5%, 3.3%, 4.9%, 2.9%, 3.7%, 2.5%, 3.6%, and 3.4% increased mean values of the same variables of group (B). Moreover, at the end of the study both groups revealed significant differences.
Conclusion: Weight loss improves immunological parameters among obese NAFLD subjects.
Keywords: Immune system; Non-alcoholic fatty liver disease; Obesity; Weight loss
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