Department of Biochemistry, All India Institute of Medical Sciences, India
*Corresponding author:Nimai Chand Chandra, Department of Biochemistry, All India Institute of Medical Sciences, India
Submission: August 02, 2019Published: September 16, 2019
ISSN : 2578-0263Volume3 Issue2
Metabolic Syndrome-X (MS-X) represents a medleybolome of several metabolic disorders from the angles of physiological, biochemical, clinical and metabolic anarchy. Diabetes, obesity and hypertension are the major medico-clinical concerns in 21st century both for developed and developing world. A great number of reports in last decades and recent past from various angles to control the pathology of MS-X have been published [1-9]. Exclusively, catching of diabetes in obese subjects is a unique feature in this disturbed metabolome. In human obesity the insulin resistance and type-2 diabetes are most often inter-linked. The feedback regulatory mechanism of hyper leptinemia is failed in human obesity [10,11]. On the other hand, hyperleptinemia develops insulin resistance. The (Figure 1) shows the metabolic interlink and dependency that reels between insulin and leptin.
Figure 1:Metabolic interlink and dependency that reels between insulin and leptin.
Keywords: Diabetes; Metabolic syndrome; Insulin; Atherosclerosis