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Abstract

Investigations in Gynecology Research & Womens Health

Adult Ovarian Granulosa Cell Tumor: Role of Systemic Chemotherapy and Surgical Treatment

  • Open or CloseBakhidze E1,2*, A Belyaeva A2 and I Berlev I1,2

    1NN Petrov Research medical center of oncology, Saint-Petersburg, Russia

    2II Mechnikov North-Western State Medical University, Saint-Petersburg, Russia

    *Corresponding author:Bakhidze E, NN Petrov Research medical center of oncology, Saint-Petersburg, Russia

Submission: January 22, 2020Published: April 15, 2020

DOI: 10.31031/IGRWH.2020.03.000566

ISSN: 2577-2015
Volume3 Issue4

Abstract

Ovarian granulosa cell tumors (GCT) are rare ovarian neoplasms. The main treatment for GCT is surgical. The volume of operation depends on the stage of the disease and the age of the patient. The possibility of maintaining fertility in patients of reproductive age in the early stages of the disease and the feasibility of lymphadenectomy are discussed. The positive effect of repeated cytoreductive operations for relapse was demonstrated. Role of chemotherapy in the treatment of GCT, due to the rarity of GCT and the late recurrence of the disease, is still not defined. Adjuvant chemotherapy is not shown to protect against relapse in patients with adult type (AGCT). Hormone therapy is considered to be a promising direction for the palliative treatment of AGCT relapses.

Keywords: Granulosa cell tumors; Relapse; Surgical treatment; Fertility-saving treatment; Chemotherapy; Hormone therapy; Aromatase inhibitors

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