Abstract

Gynaecological disorders and malignancies affect the female reproductive system. Every woman in her life time suffers from gynaecological problem at some extent. The development and pathogenesis of gynaecological disorders is still remains unclear, several clinical and epidemiological studies have documented that they can be triggered by environmental, life-style, genetic factors and epigenetic alterations.The KRAS (Kristen rat sarcoma viral oncogene) gene is the commonly mutated oncogene. This gene provides instructions for making a protein called as K-Ras, which plays a vital role in cell division, differentiation and apoptosis. The frequency of mutations in this oncogene is highly reported in gynaecological cancers. This review highlights the common mutations observed in KRAS gene that is associated with breast, cervical, ovarian and endometrial cancer. These genetic variations can be considered with their clinical significance and might be used as diagnostic biomarkers and testing for RAS pathway mutations.

Keywords: KRAS; Mutation; Gynaecological malignancies; Breast cancer; Cervical cancer