Abstract

The objective of this work is to synthesize and characterization of nickel ferrite as MRI contrast agent to improve the signal intensity of T2 weighted images for biomedical application. For structural analysis, XRD was revealed that Ni-doped Fe2O4 have a cubic spinal structure Having Miller Indices (hkl) values of (220), (311), (222), (400), (331), (442), (333), (440) and (531). From XRD data, the grain size of Ni Fe2O4 was observed to be (17.12nm) after 20wt.% Ni-doped Fe2O4, and its further increases up to19.36nm for 40wt.% Ni Fe2O4, respectively. The XRD pattern confirmed that doping of Ni metal increased the grain size of nanoparticles. SEM was performed to study the morphology of prepared samples. EDX was performed to confirm the elemental analysis. EDX spectra depicted the desired peaks of Fe, O, Cl, and Ni for Ni-doped Fe3O4. Saturation magnetization (Ms) was improved with concentration of dopant material Ni (20wt.%, 40wt.% ) in magnetic nanoparticles. In essence, this study demonstrates the very easy way of synthesis of Ni doped iron oxides nanoparticles for biomedical applications as MRI contrast agents

Keywords: Nickel ferrites; Magnetic nanoparticles; MRI contrast agents; T2-Weighted