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Abstract
Gastroenterology Medicine & Research
The Duodenum: Its Role as a Metabolic Center and Clinical Implications
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Open or CloseRazan Aburumman*
The University of Jordan, Jordan
*Corresponding author:Razan Aburumman, The University of Jordan, Jordan
Submission: October 08, 2025;Published: October 29, 2025
ISSN 2637-7632Volume8 Issue 2
Common metabolic diseases, such as type 2 diabetes (T2DM), obesity, and Metabolic Dysfunction- Associated Steatotic Liver Disease (MASLD), have become a global health burden. In recent years, the glucoregulatory function of the duodenum has been more clearly understood, with studies indicating that changes in the morphology and function of the duodenal mucosa may significantly contribute to the development of metabolic diseases. Interventions such as Roux-en-Y gastric bypass and Duodenal Mucosal Resurfacing (DMR) have demonstrated significant improvements in glycemic control, suggesting that targeting the duodenum may offer novel therapeutic approaches for managing metabolic diseases.
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